What are the differential diagnoses for condyloma (Human Papillomavirus or HPV)?

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Differential Diagnosis for Genital Wart Lookalikes

  • Single Most Likely Diagnosis
    • Condyloma lata (secondary syphilis): This condition can present with lesions that resemble genital warts, making it a key consideration in the differential diagnosis. The lesions in condyloma lata are often flat, broad, and moist, distinguishing them from the typically raised and verrucous appearance of genital warts.
  • Other Likely Diagnoses
    • Molluscum contagiosum: This viral infection causes small, pearly, or flesh-colored lesions that can be mistaken for genital warts. The lesions are usually dome-shaped and have a central depression.
    • Seborrheic keratoses: These benign growths can appear in the genital area and may resemble genital warts, especially if they become irritated or inflamed.
    • Fordyce spots: These small, yellowish or white bumps on the genitals are caused by ectopic sebaceous glands and can be mistaken for genital warts.
  • Do Not Miss Diagnoses
    • Squamous cell carcinoma: Although rare, this type of skin cancer can present with lesions that resemble genital warts. It is crucial to biopsy any suspicious or atypical lesions to rule out malignancy.
    • Basal cell carcinoma: Another type of skin cancer that can occur in the genital area, basal cell carcinoma may present with lesions that could be mistaken for genital warts.
  • Rare Diagnoses
    • Lichen planus: This chronic inflammatory condition can cause lesions in the genital area that may resemble genital warts, although they are typically flat and purplish in color.
    • Psoriasis: Genital psoriasis can cause red, scaly plaques that may be mistaken for genital warts, especially if the lesions become secondarily infected.
    • Vestibular papillomatosis: This benign condition causes small, finger-like projections on the vulvar vestibule and can be mistaken for genital warts.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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