Dehydration: This is often the most common cause of increased creatinine, as decreased blood volume can lead to reduced renal perfusion, resulting in elevated creatinine levels. Dehydration can be due to various reasons such as inadequate fluid intake, excessive fluid loss (e.g., diarrhea, vomiting), or certain medications.

Acute Kidney Injury (AKI): Conditions like sepsis, shock, or nephrotoxic medications can cause AKI, leading to increased creatinine levels.
Chronic Kidney Disease (CKD): Prolonged kidney damage or disease can result in elevated creatinine levels due to decreased kidney function.
Medication-induced nephrotoxicity: Certain medications, such as NSAIDs, aminoglycosides, or contrast agents, can cause kidney damage, leading to increased creatinine levels.

Rhabdomyolysis: This condition, characterized by muscle breakdown, can lead to acute kidney injury and increased creatinine levels. It is crucial to identify and treat promptly to prevent long-term kidney damage.
Urinary tract obstruction: Obstruction of the urinary tract, such as kidney stones or bladder outlet obstruction, can cause increased creatinine levels and requires prompt intervention to prevent kidney damage.
Vasculitis: Inflammatory conditions like vasculitis can affect the kidneys and cause increased creatinine levels. Early diagnosis and treatment are essential to prevent long-term damage.

Myeloma kidney: This condition occurs when abnormal proteins produced by myeloma cells damage the kidneys, leading to increased creatinine levels.
Amyloidosis: A group of diseases characterized by the deposition of abnormal proteins in the kidneys, which can cause increased creatinine levels.
Glomerulonephritis: Inflammatory conditions that affect the glomeruli, such as post-streptococcal glomerulonephritis or IgA nephropathy, can cause increased creatinine levels.