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Last updated: October 7, 2025View editorial policy

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Differential Diagnosis for a 5-Month-Old with Congestion and Runny Nose

Single Most Likely Diagnosis

  • Viral Upper Respiratory Tract Infection (URTI): This is the most common cause of congestion and runny nose in infants, often caused by viruses such as rhinovirus, coronavirus, or adenovirus. The symptoms presented are typical for a viral URTI, and the age of the patient and the duration of symptoms support this diagnosis.

Other Likely Diagnoses

  • Allergic Rhinitis: Although less common in infants, allergic rhinitis can cause similar symptoms. However, it would typically be associated with other signs of allergy, such as eczema or a family history of allergies.
  • Vasomotor Rhinitis: This condition can cause nasal congestion and discharge due to non-allergic, non-infectious factors, but it's less common in infants.

Do Not Miss Diagnoses

  • Bacterial Sinusitis: Although less likely than viral URTI, bacterial sinusitis can occur, especially if symptoms worsen or persist beyond 7-10 days. It's crucial to consider this diagnosis due to the potential need for antibiotic treatment.
  • Influenza: Especially during flu season, influenza can cause severe illness in infants and requires prompt diagnosis and treatment.
  • Respiratory Syncytial Virus (RSV) Infection: RSV can cause mild to severe illness in young children, including bronchiolitis and pneumonia, making it a critical diagnosis not to miss.

Rare Diagnoses

  • Cystic Fibrosis: While rare, cystic fibrosis can present with recurrent respiratory infections and nasal congestion. It's essential to consider in infants with persistent or severe symptoms.
  • Choanal Atresia: A congenital condition where the nasal passage is blocked, which can cause respiratory distress and nasal congestion, especially noticeable in newborns but can be diagnosed later if symptoms persist.
  • Immunodeficiency: Certain immunodeficiencies can predispose infants to recurrent or severe infections, including those causing congestion and runny nose.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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