From the Guidelines
CBD and CBN are distinct cannabinoids with different properties and effects, where CBD is non-psychoactive and widely used for therapeutic benefits, whereas CBN is mildly psychoactive with sedative properties. The key difference between the two lies in their interaction with the body's endocannabinoid system and the receptors they bind to. CBD is not an agonist at either CB1 or CB2 receptors, but rather a negative allosteric modulator 1, which contributes to its non-psychoactive effects. In contrast, CBN is formed when THC ages and oxidizes, and its effects are less studied compared to CBD.
Key Differences
- CBD is non-psychoactive and has been extensively studied for its potential therapeutic benefits, including anxiety reduction, pain relief, and anti-inflammatory effects.
- CBN is mildly psychoactive and primarily known for its sedative properties, with potential benefits for sleep.
- CBD is directly extracted from the cannabis plant and is found in higher concentrations, whereas CBN forms through the aging and oxidation of THC.
- Both compounds interact with the body's endocannabinoid system but bind to different receptors, explaining their distinct effects.
Clinical Implications
When considering either CBD or CBN, it is essential to start with low doses and be aware that products vary widely in quality and concentration. CBD products are more widely available and regulated than CBN products. The clinical effects of cannabis and its compounds, including CBD and CBN, can vary with the quantity consumed and the chronicity of use, affecting multiple organ systems such as the CNS, cardiovascular system, and respiratory system 1.
Recommendations
Given the current understanding and the difference in research support, CBD is recommended for its therapeutic benefits due to its extensive study and inclusion in FDA-approved medications, whereas CBN's effects, though promising, require more research for definitive conclusions. Always prioritize products from reputable sources and follow guidelines for safe use.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Difference between Cannabidiol (CBD) and Cannabinol (CBN)
- CBD and CBN are two distinct cannabinoids found in the Cannabis sativa plant, with different effects on the human body 2, 3.
- CBD is a non-psychoactive compound, whereas CBN is a psychoactive compound, although its effects are generally considered to be milder than those of THC 4, 3.
- Research on the therapeutic effects of CBD and CBN is ongoing, with some studies suggesting that CBD may have anxiolytic and anti-addiction effects, while CBN may have sedative and sleep-promoting effects 2, 3, 5.
- A study comparing the effects of CBD and CBN on sleep found that both compounds led to significant improvements in sleep disturbance, although the addition of CBN to CBD did not appear to enhance its effects 2.
- Another study investigating the effects of CBN on sleep in individuals with insomnia disorder found that CBN had a positive effect on sleep quality, although the results are preliminary and require further confirmation 3.
Therapeutic Effects
- CBD has been studied for its potential therapeutic effects on anxiety, insomnia, neurological disorders, and chronic pain, with some evidence suggesting its efficacy at doses greater than or equal to 300mg 5.
- CBN has been studied for its potential therapeutic effects on sleep disorders, with some evidence suggesting its efficacy in improving sleep quality 3.
- The safety and efficacy of low oral doses of CBD and CBN are still being evaluated, with more research needed to confirm their therapeutic potential 2, 5.
Comparison of CBD and CBN
- A comparison of the effects of CBD and CBN on sleep found that both compounds had similar effects, although the study was limited by its small sample size and short duration 2.
- Further research is needed to fully understand the differences between CBD and CBN, including their therapeutic effects, safety profiles, and potential interactions with other medications 4, 6, 5.