From the Guidelines
CBN and CBD are distinct cannabinoids with different properties and effects, where CBD is known for its potential anti-anxiety, anti-inflammatory, and pain-relieving properties, and CBN is primarily recognized for its sedative effects. The key difference between the two lies in their interaction with the body's systems and their effects on the user. CBD, as noted in the study by Ladha et al. 1, is a negative allosteric modulator of the cannabinoid receptor and has been shown to reduce the adverse effects of THC in human studies, potentially increasing endocannabinoid signalling and affecting serotonin receptor 1A activity. On the other hand, CBN forms when THC ages and oxidizes, and it is less potent than THC, with a mild affinity for CB1 receptors in the brain.
Some of the main differences between CBN and CBD include:
- Their origin: CBD is more abundant in cannabis plants, while CBN is formed through the aging and oxidation of THC.
- Their effects: CBD is known for its potential anti-anxiety, anti-inflammatory, and pain-relieving properties, whereas CBN is recognized for its sedative effects.
- Their interaction with the body: CBD interacts with multiple body systems, including serotonin receptors, while CBN has a mild affinity for CB1 receptors in the brain.
- Their potency: CBN is much less potent than THC, and CBD does not produce the high associated with THC.
The study by Ladha et al. 1 highlights the potential benefits of CBD in treating chronic pain, chemotherapy-induced nausea and vomiting, spasticity associated with multiple sclerosis, obstructive sleep apnoea, and fibromyalgia. However, more research is needed to fully understand the effects of CBN and its potential benefits. In terms of dosage, CBD is typically available in doses ranging from 10-50mg per serving for general wellness, while CBN is often used in doses of 5-10mg for sleep aids. Overall, while both CBN and CBD have potential benefits, CBD has more research supporting its effects, and CBN research is still emerging.
From the Research
Difference between Cannabinol (CBN) and Cannabidiol (CBD)
- There is no direct comparison between CBN and CBD in the provided studies, as they primarily focus on the effects and potential benefits of CBD.
- The studies discuss the interaction of CBD with the endocannabinoid system, its potential benefits for various medical and psychiatric conditions, and its differences from other cannabinoids like THC 2, 3, 4, 5.
- One study mentions cannabigerol (CBG), another cannabinoid, and its unique interactions with cannabinoid receptors and other targets, but does not compare it directly to CBN 6.
- Since CBN is not mentioned in the provided studies, there is no research-based information available to directly compare CBN and CBD.