From the Research
CoQ10 supplementation is recommended for women trying to conceive, especially those over 35 or with diminished ovarian reserve, as it may improve oocyte quality and subsequent reproductive performance, as suggested by the most recent study in 2023 1. The recommended dosage is 200-600 mg of CoQ10 daily, divided into two doses with meals to improve absorption.
- The ubiquinol form is generally considered more bioavailable than ubiquinone.
- CoQ10 works as an antioxidant that may protect eggs from oxidative damage and supports mitochondrial function, which is crucial for egg energy production and quality.
- The theoretical benefit stems from CoQ10's role in cellular energy production, as egg cells require significant energy for proper development and division.
- While some fertility specialists recommend it as part of a preconception regimen, results vary between individuals, and it may take 3-6 months of supplementation to see potential benefits.
- CoQ10 is generally considered safe with minimal side effects, though you should consult with a healthcare provider before starting, especially if you're taking blood thinners or other medications. The most recent and highest quality study, published in 2023 in the journal Human Fertility, found that CoQ10 supplementation improved fertilization rates, embryo maturation rates, and embryo quality in women aged 31 and over 1.
- This study also found that CoQ10 reduced high rates of chromosomal abnormalities and oocyte fragmentation, as well as improved mitochondrial function.
- Another recent study, published in 2023 in the journal Vitamins and Hormones, found that CoQ10 supplementation had beneficial antioxidant effects on reproduction and may improve reproductive performance by scavenging reactive oxygen species and free radicals 2. It is essential to note that while the evidence is promising, more research is needed to confirm the effectiveness of CoQ10 supplementation for improving oocyte quality and reproductive outcomes.
- However, based on the current evidence, CoQ10 supplementation appears to be a low-risk and potentially beneficial strategy for women trying to conceive, especially those over 35 or with diminished ovarian reserve.
- As always, it is crucial to consult with a healthcare provider before starting any new supplement regimen, especially if you're taking other medications or have underlying health conditions.