Can Vyvanse (lisdexamfetamine) be sprinkled on food?

Administration of Vyvanse (Lisdexamfetamine) with Food

Yes, Vyvanse (lisdexamfetamine) capsules can be opened and sprinkled on food as an alternative administration method. According to the FDA drug label, if Vyvanse capsules cannot be swallowed whole, the capsule may be opened and the entire contents sprinkled onto yogurt, or poured into water or orange juice 1.

Proper Administration Method

When sprinkling Vyvanse on food, follow these specific steps:

• Open the capsule and sprinkle the entire contents onto yogurt or pour into water or orange juice 1
• Using a spoon, break apart any powder that is stuck together 1
• Stir the lisdexamfetamine powder and yogurt, water, or orange juice until completely mixed 1
• Consume the entire mixture immediately - do not store the mixture for later use 1
• A filmy coating may appear on the inside of your glass or container after consuming the mixture - this is normal 1

Clinical Considerations

Timing and Dosing

• Vyvanse should be taken once daily in the morning, with or without food 1
• The usual starting dose is 20-30 mg once daily, with titration typically increasing by 10 mg weekly to a maximum of 70 mg daily 2

Pharmacokinetic Properties

• Lisdexamfetamine is a prodrug that is converted to dextroamphetamine after ingestion 2
• The prodrug formulation provides several advantages:
  • Lower abuse potential compared to other stimulants 2
  • More difficult extraction of the stimulant component 2
  • Long-acting properties with effects lasting up to 14 hours post-dose in adults 3

Important Precautions

• Vyvanse is a federally controlled substance (CII) and should be kept in a safe place to protect from theft 1
• Never give Vyvanse to anyone else as it may cause harm or death 1
• Monitor for potential side effects, which commonly include:
  • Loss of appetite/decreased appetite 1
  • Anxiety 1
  • Dry mouth 1
  • Insomnia 1
  • Irritability 1

Common Pitfalls to Avoid

• Do not store the mixture of Vyvanse with food or liquid for later use - it must be consumed immediately after mixing 1
• Do not crush tablets or open capsules of medications without first verifying it is safe to do so, as this can potentially alter drug absorption and lead to overdose or underdosing with some medications 4
• Avoid using household utensils (like teaspoons) for measuring liquid medications, as this can lead to dosing errors 5
• Be aware that Vyvanse may interact with certain medications, including MAOIs, so inform healthcare providers about all medications being taken 1

By following these guidelines, Vyvanse can be safely administered by sprinkling on food when patients have difficulty swallowing the capsule whole.