From the Guidelines
Do not store an insulin degludec (Tresiba) pen in a freezer, as this can cause the insulin to become ineffective and potentially lead to high blood sugar levels. The storage guidelines for insulin emphasize the importance of avoiding extreme temperatures, including freezing, to prevent loss of potency and damage to the insulin 1.
Storage Recommendations
- Insulin degludec should be stored in the refrigerator at a temperature between 36-46°F (2-8°C) before first use.
- After first use, the pen can be kept at room temperature (below 86°F or 30°C) for up to 56 days.
- Freezing disrupts the insulin's molecular structure, causing it to break down and lose its blood glucose-lowering ability.
Important Considerations
- If an insulin degludec pen is accidentally frozen, it should be discarded and replaced, even if it appears normal.
- Always check insulin for changes in appearance (cloudiness, particles, discoloration) before use, as these may indicate damage 1.
Key Points to Remember
- Avoid extreme temperatures and excess agitation to prevent loss of potency and damage to the insulin.
- Follow the specific storage guidelines provided by the manufacturer to ensure the insulin's effectiveness and safety.
From the FDA Drug Label
Do not freeze Insulin Degludec Do not use Insulin Degludec if it has been frozen.
The insulin degludec (Tresiba) pen should not be stored in a freezer. If it has been frozen, it should not be used. 2
From the Research
Storage Conditions for Insulin Degludec
- The provided studies do not specifically address the storage of insulin degludec (Tresiba) pens in a freezer 3, 4, 5, 6, 7.
- However, it is generally recommended to store insulin at temperatures between 2°C and 8°C to maintain its potency and stability 3.
- Freezing insulin can cause it to degrade and lose its effectiveness, and it is not a recommended storage condition 3.
- The studies suggest that insulin can be stored at room temperature for a certain period, but the exact duration and temperature range may vary depending on the type of insulin and the manufacturer's recommendations 3, 4.
- It is essential to follow the manufacturer's instructions for storing insulin degludec and to consult with a healthcare professional if there are any concerns about storage or handling 5, 6, 7.
Recommendations for Insulin Storage
- Store insulin in a cool, dry place, away from direct sunlight and heat sources 3.
- Refrigerate insulin at a temperature between 2°C and 8°C to maintain its potency and stability 3.
- Avoid freezing insulin, as it can cause degradation and loss of effectiveness 3.
- Follow the manufacturer's instructions for storing insulin degludec and consult with a healthcare professional if there are any concerns 5, 6, 7.