Storage Requirements for Brixadi (Buprenorphine)
Brixadi should be stored in the refrigerator at 4°C (39°F) to maintain its stability and potency.
Storage Guidelines for Brixadi
- Brixadi should be stored in a refrigerator at approximately 4°C (39°F) to maintain optimal stability 1
- Medications containing buprenorphine require proper storage to maintain their efficacy and safety profile 2
- Like other medications requiring refrigeration, Brixadi should be stored in a designated medication refrigerator that maintains a consistent temperature range, ideally around 5°C 3
- The medication should be kept in its original container with appropriate labeling to ensure proper identification 1
Rationale for Refrigeration
- Buprenorphine formulations stored in glass vials retain more than 90% of their initial concentration when refrigerated for extended periods (up to 180 days) 2
- Proper refrigeration helps prevent degradation of the medication and maintains its therapeutic properties 3
- Medications requiring refrigeration should be stored separately from food items in a dedicated medication refrigerator 1
Important Considerations
- Brixadi should be protected from light during storage, as some buprenorphine formulations may be sensitive to light exposure 2
- The medication should not be frozen, as freezing can potentially alter the stability and efficacy of injectable medications 4
- When transporting Brixadi between locations, it should be kept at the recommended temperature using appropriate cooling containers to maintain the cold chain 3
Security Requirements
- All prescription medications, including Brixadi, should be stored securely in accordance with applicable regulations 1
- Controlled substances must be double-locked to prevent unauthorized access 1
- The medication should be accessible only to authorized healthcare personnel who are responsible for its administration 1
Common Pitfalls to Avoid
- Avoid storing Brixadi in plastic syringes for extended periods, as studies show significant degradation of buprenorphine when stored in plastic (up to 28% loss even when refrigerated) 2
- Do not store the medication in areas with temperature fluctuations, such as door shelves of refrigerators 3
- Avoid exposing the medication to extreme temperatures that could compromise its integrity 4
- Do not store beyond the manufacturer's expiration date, regardless of storage conditions 1