Storage Requirements for Brixadi (Buprenorphine)
If Brixadi (buprenorphine) is not stored in the refrigerator, it may lose potency and effectiveness, potentially compromising patient treatment outcomes.
Proper Storage Requirements
- Brixadi should be stored in a refrigerator at approximately 4°C (39°F) to maintain optimal stability and therapeutic efficacy 1
- The medication must be kept in its original container with appropriate labeling to ensure proper identification and tracking 1
- Refrigeration helps prevent degradation of the active pharmaceutical ingredient, which is crucial for maintaining the intended therapeutic effect 2
Consequences of Improper Storage
- Storing Brixadi outside refrigeration can accelerate degradation of the medication, potentially reducing its effectiveness in treating opioid use disorder 1
- Temperature excursions outside the recommended range can compromise the stability and potency of the medication 3
- Since buprenorphine is used for opioid use disorder treatment, reduced efficacy due to improper storage could negatively impact patient outcomes including increased risk of relapse 4
Security and Handling Considerations
- All controlled substances, including Brixadi, must be stored securely with double-lock protection to prevent unauthorized access 1
- The medication should be accessible only to authorized healthcare personnel responsible for its administration 1
- Expired medication should be discarded regardless of storage conditions 1
Practical Recommendations
- If Brixadi is accidentally left unrefrigerated, check with the manufacturer or pharmacy regarding potential usability timeframes 5
- When transporting Brixadi, use cooler packs or insulated bags to maintain the appropriate temperature range 5
- Before administration, always inspect the medication visually for any changes in appearance that might indicate degradation 5
Common Pitfalls to Avoid
- Household refrigerators commonly operate outside the ideal temperature range for medication storage; consider using a dedicated medication refrigerator with temperature monitoring 5
- Never freeze Brixadi as this can alter its molecular structure and potentially render it ineffective 5
- Avoid exposing the medication to direct heat, light, or excessive agitation as these factors can accelerate degradation 5