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Differential Diagnosis for Fever in a 70-year-old Man with Type 2 DM and Acalculous Cholecystitis

Single Most Likely Diagnosis

  • Acalculous cholecystitis with bacterial infection: Given the patient's presentation with high-grade fever, chills, and ultrasound findings of acalculus cholecystitis, the most likely cause of fever is a bacterial infection of the gallbladder. The patient's poorly controlled diabetes (HbA1c of 13) increases the risk of infections, including those of the gallbladder.

Other Likely Diagnoses

  • Sepsis secondary to another source: Although the focus is on acalculus cholecystitis, the patient's high fever and chills could also indicate sepsis originating from another source, such as a urinary tract infection, pneumonia, or a skin infection, which are common in elderly patients, especially those with diabetes.
  • Diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar nonketotic syndrome (HHNS): Poorly controlled diabetes can lead to these conditions, which may present with fever, although they are not infections per se. The high HbA1c level suggests a possibility of these metabolic emergencies.

Do Not Miss Diagnoses

  • Endocarditis: Although less likely, infective endocarditis can present with fever and systemic symptoms and is a diagnosis that should not be missed due to its high mortality rate if untreated. The presence of chills could suggest bacteremia.
  • Intra-abdominal infection other than cholecystitis: Other abdominal infections, such as diverticulitis or perforated viscus, could present similarly and require urgent surgical intervention.

Rare Diagnoses

  • Fungal infection: In immunocompromised patients, such as those with very poorly controlled diabetes, fungal infections can occur, including fungal cholecystitis, although this is much less common than bacterial causes.
  • Malignancy: Rarely, a malignancy involving the gallbladder could present with fever and chills, although this would be an uncommon initial presentation.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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