From the Guidelines
The brain is the most commonly affected organ in metastatic breast cancer, particularly in patients with HER2-positive disease, with up to half of patients experiencing brain metastases over time. This is a critical consideration for morbidity, mortality, and quality of life, as brain metastases can lead to significant neurological symptoms and decreased survival 1. The development of brain metastases is a known risk factor for patients with HER2-positive breast cancer, and the incidence of brain metastases has been increasing as systemic therapies for extracranial disease improve 1.
Key points to consider in the management of metastatic breast cancer include:
- The brain is a common site of metastasis, particularly in HER2-positive disease
- Brain metastases can occur in a continuous fashion, even after many years from initial metastatic diagnosis 1
- Systemic therapies for control of extracranial disease can improve survival, but brain metastases remain a significant concern 1
- Monitoring for brain metastases and prompt treatment are essential to improve outcomes and quality of life 1
In terms of treatment, systemic therapy based on the cancer's receptor status is typically used, and may include endocrine therapy, targeted therapies, or chemotherapy 1. Local treatments such as stereotactic body radiation therapy may also be considered for isolated metastases 1. The most recent and highest quality study suggests that brain metastases are a major concern in metastatic breast cancer, particularly in HER2-positive disease, and highlights the need for prompt and effective treatment to improve outcomes and quality of life 1.
From the Research
Organ Affected by Metastatic Breast Cancer
- The most commonly affected organ in metastatic breast cancer is not explicitly stated in the provided studies as the most common site. However, based on the information provided:
- Brain metastases are a significant concern in metastatic breast cancer, with approximately 20%-30% of patients developing brain metastases 2.
- The incidence of brain metastases is increasing due to improved systemic control and more routine surveillance imaging 3.
- Brain metastases from breast cancer constitute the second most common cause of brain metastasis, and the incidence of these lesions is currently increasing 4.
- Breast cancer is a common cause of brain metastases, with metastases occurring in at least 10-16% of patients 5.
- Other studies focus on the treatment and management of brain metastases, indicating the significance of this issue in metastatic breast cancer 6.