From the Research
The most common causes of Ankylosing Spondylitis (AS) in the United States are associated with genetic variables, demographic factors, and environmental variables, with the human leukocyte antigen B27 (HLA-B27) variation being the most significant gene associated with AS susceptibility, as reported in the most recent study 1. The etiology of AS is complicated and involves multiple factors, including age of onset, gender, ethnicity, and family history. According to the study published in 2024 1, AS typically manifests in males in their third decade. The HLA-B27 variation is currently the most significant gene associated with AS susceptibility, with over 100 genes connected to AS susceptibility. Key factors that contribute to the development of AS include:
- Genetic factors, such as the HLA-B27 variation
- Demographic factors, such as age of onset, gender, ethnicity, and family history
- Environmental variables, which are not fully understood
- The presence of other inflammatory conditions, such as uveitis or psoriasis It is essential to note that the diagnosis of AS can be challenging, and early inflammatory alterations can be found using modern diagnostic tools such as MRI, with the HLA-B27 gene helping to confirm the diagnosis. The diagnosis and treatment of AS should be guided by the most recent and highest-quality evidence, with a focus on improving patient outcomes and quality of life, as emphasized in the study published in 2024 1.