From the FDA Drug Label
PRECAUTIONS: General Investigate any tachycardia before giving Glycopyrrolate Injection since an increase in the heart rate may occur. ADVERSE REACTIONS: ...tachycardia; palpitation;...
Tachycardia is a potential effect of glycopyrrolate, as it may cause an increase in heart rate. Key points to consider:
- The drug label warns to investigate any tachycardia before giving glycopyrrolate injection 1
- Tachycardia is listed as a potential adverse reaction to glycopyrrolate 1 Therefore, glycopyrrolate may cause tachycardia. 1 1
From the Research
Glycopyrrolate is not typically associated with causing tachycardia, according to the most recent and highest quality study available 2. This anticholinergic medication blocks muscarinic receptors, which can have various effects on the body. However, the primary concern with glycopyrrolate is its potential to cause anticholinergic side effects such as dry mouth, blurred vision, urinary retention, and constipation. In terms of cardiac effects, the study from 2015 3 found that glycopyrronium did not result in an increased risk of cerebro-cardiovascular events compared to placebo, suggesting that it may not have a significant impact on heart rate. Another study from 1989 4 found that glycopyrronium can cause increases in heart rate, but this effect was more pronounced at higher doses. A more recent study from 2014 5 found that the combination of glycopyrrolate and atropine did not cause a significant increase in heart rate compared to atropine alone. Overall, the evidence suggests that glycopyrrolate is not typically associated with causing tachycardia, but it can cause other anticholinergic side effects. Some key points to consider when prescribing glycopyrrolate include:
- Monitoring for anticholinergic side effects such as dry mouth, blurred vision, urinary retention, and constipation
- Using caution in patients with a history of cardiac arrhythmias, coronary artery disease, or heart failure
- Considering alternative medications or dose adjustments if patients experience persistent or severe side effects
- Educating patients about the potential risks and benefits of glycopyrrolate and the importance of reporting any side effects to their healthcare provider.