Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 13, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for General Joint Pain and Bloodshot Eyes

  • Single Most Likely Diagnosis
    • Rheumatoid Arthritis (RA): This condition often presents with symmetric joint pain and inflammation, and while not directly causing bloodshot eyes, the associated inflammation can lead to secondary conditions like scleritis or episcleritis, which could cause the eye symptoms.
  • Other Likely Diagnoses
    • Reactive Arthritis: Previously known as Reiter's syndrome, this form of arthritis occurs as a reaction to an infection elsewhere in the body, often presenting with joint pain, eye inflammation (which could cause bloodshot eyes), and sometimes urethritis.
    • Psoriatic Arthritis: A condition that combines the swollen, scaly skin of psoriasis with joint pain and arthritis, and can also include eye symptoms like conjunctivitis or uveitis, leading to bloodshot eyes.
    • Lupus: Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect various parts of the body, including the joints and eyes, causing pain and inflammation in these areas.
  • Do Not Miss Diagnoses
    • Giant Cell Arteritis: Although less common, this condition can cause severe eye symptoms, including sudden vision loss if not promptly treated, and can also present with joint pain.
    • Sarcoidosis: An autoimmune disease that can affect multiple parts of the body, including the eyes (causing uveitis) and joints, and if missed, can lead to serious complications.
    • Lyme Disease: In its later stages, Lyme disease can cause arthritis and, in some cases, eye inflammation, making it a critical diagnosis not to miss due to its potential for serious complications if left untreated.
  • Rare Diagnoses
    • Relapsing Polychondritis: A rare autoimmune disorder that can cause inflammation in various cartilaginous structures, including the eyes and joints, leading to symptoms like bloodshot eyes and joint pain.
    • Behçet's Disease: A form of vasculitis that can cause a wide range of symptoms, including joint pain, bloodshot eyes (due to uveitis), and oral or genital ulcers, making it a rare but important consideration in the differential diagnosis.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.