From the Research
Ceftaroline can be used in breastfeeding mothers with caution, as the risk to the nursing infant appears to be minimal, based on its pharmacokinetic properties and the general safety of cephalosporins during breastfeeding 1. The use of ceftaroline in breastfeeding mothers is supported by the fact that most cephalosporins are considered compatible with breastfeeding by the American Academy of Pediatrics.
- The typical adult dose of ceftaroline is 600 mg administered intravenously every 12 hours for 5-14 days, depending on the type of infection being treated.
- Dose adjustments may be necessary for patients with renal impairment.
- Mothers should monitor their infants for potential side effects such as diarrhea, thrush, or changes in feeding patterns, although these are unlikely. The rationale for considering ceftaroline relatively safe during breastfeeding relates to its pharmacokinetic properties, including poor oral bioavailability, which suggests that any drug present in breast milk would be poorly absorbed by the infant's gastrointestinal tract, as well as its molecular weight and protein binding characteristics, which suggest limited transfer into breast milk 2.
- It is essential to consult reliable sources, such as LactMed, for the most up-to-date information on the safety of medications during breastfeeding 1.
- The benefits of breastfeeding, including its numerous beneficial effects on child and maternal health, should be considered when making decisions about medication use during lactation 3.
- In general, most medications can be used safely during breastfeeding at the recommended dose, with some exceptions that necessitate caution 4.
- When prescribing medications for breastfeeding mothers, it is crucial to choose the safest drug available, taking into account factors such as the drug's pharmacokinetics, risk to the infant, and impact on lactation 5.