What are the side effects of Cannabidiol (CBD) gummies?

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Last updated: March 24, 2025View editorial policy

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From the Guidelines

CBD gummies can cause significant side effects, including dizziness, confusion, dry mouth, and fatigue, as well as more serious effects like tachycardia, orthostatic hypotension, severe confusion, and paranoia, particularly if not dosed and titrated appropriately 1. When considering the use of CBD gummies, it is essential to be aware of the potential short- and long-term risks associated with their use. Some of the common side effects of CBD gummies include:

  • Dizziness
  • Confusion
  • Dry mouth
  • Fatigue These side effects can be mitigated by starting with a low dose and slowly increasing until the desired effect is achieved, particularly in older adults and those who are naïve to cannabis and/or cannabinoids 1. Additionally, CBD presents risks for hepatotoxicity, which is a significant concern for users 1. It is crucial to be aware of the potential for cannabis and/or cannabinoid overdoses, which can be distressing and may place an individual at high risk for falls and healthcare utilization 1. To minimize adverse effects, it is recommended to:
  • Start with a low dose and slowly increase until the desired effect is achieved
  • Be aware of the potential for interactions with medications, particularly those metabolized by the liver's cytochrome P450 enzyme system
  • Consult with a healthcare provider before using CBD products, especially if taking prescription medications 1.

From the FDA Drug Label

The FDA drug label does not answer the question.

From the Research

Side Effects of Cannabidiol (CBD) Gummies

  • The side effects of CBD gummies are similar to those of other CBD products, and include:
    • Transaminase elevations 2
    • Sedation 2, 3
    • Sleep disturbances 2
    • Infection 2
    • Anemia 2
    • Diarrhoea 3
    • Decreased appetite 3
    • Somnolence 3
    • Sedation 3
  • CBD can also interact with other medications, including:
    • Clobazam 3
    • Sodium valproate 3
    • Other medications that are metabolized by CYP3A4/2C19 2
  • The risk of adverse effects may be higher in certain populations, such as:
    • Children with epilepsy 3
    • Medically complex patients 2
  • It is essential to monitor for adverse effects and drug-drug interactions when using CBD gummies, especially in populations that are at higher risk 2, 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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