Post-Injection Protocol After Intraarticular PRP Knee Injection
After an intraarticular PRP knee injection, patients should follow a limited activity protocol for 24-48 hours followed by a gradual return to normal activities and implementation of a structured rehabilitation program to maximize therapeutic benefits. 1, 2
Immediate Post-Injection Protocol (First 24-48 Hours)
- Restrict strenuous activities and avoid weight-bearing exercise for 24-48 hours to allow the platelets to adhere to the tissue and begin releasing growth factors 2
- Apply ice to the injection site for 15-20 minutes every 2-3 hours if experiencing post-injection pain or swelling 1
- Avoid use of NSAIDs for at least 7 days post-injection as they may interfere with the inflammatory cascade necessary for PRP effectiveness 2
- Mild analgesics such as acetaminophen may be used if needed for post-injection discomfort 2
Short-Term Protocol (Days 3-14)
- Gradually return to normal daily activities while avoiding high-impact activities 3
- Begin gentle range of motion exercises to prevent stiffness and maintain joint mobility 4
- Light walking is encouraged to promote circulation and healing 2
- Continue to avoid NSAIDs during this period 2
Medium-Term Protocol (Weeks 2-6)
- Implement a progressive exercise program focusing on:
- Gradually increase activity level based on symptoms 5
- Consider physical therapy to optimize outcomes 2
Long-Term Protocol (Beyond 6 Weeks)
- Continue with progressive strengthening and conditioning exercises 2
- Return to normal activities as tolerated, with gradual reintroduction of higher-impact activities 3
- Monitor symptoms and adjust activity levels accordingly 5
Important Considerations
- The American Academy of Orthopaedic Surgeons (AAOS) notes that PRP may reduce pain and improve function in patients with symptomatic osteoarthritis of the knee, though evidence is limited 6
- Multiple studies show that the maximum therapeutic effect of PRP typically occurs between 1-3 months post-injection 5, 3
- Some protocols involve multiple injections (2-3) at monthly intervals for optimal results 3
- Patients should be informed that results may vary, with some studies showing inconsistent outcomes, particularly in severe knee osteoarthritis 1, 2
Common Pitfalls to Avoid
- Using NSAIDs too soon after injection, which may inhibit the inflammatory response necessary for PRP effectiveness 2
- Returning to high-impact activities too quickly, which may compromise treatment outcomes 3
- Expecting immediate results, as the therapeutic effects of PRP typically develop gradually over several weeks 5
- Neglecting the importance of a structured rehabilitation program, which is essential for optimizing outcomes 2, 4