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Last updated: October 16, 2025View editorial policy

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Differential Diagnosis

The patient's symptoms, including a rough barking cough, hoarseness of voice, and moderate hyperemia of the oropharyngeal mucosa, suggest a respiratory infection. Here's a breakdown of the differential diagnosis:

  • Single Most Likely Diagnosis

    • Parainfluenza: This virus is known to cause croup, which is characterized by a barking cough, hoarseness, and difficulty breathing, especially in children and young adults. The patient's symptoms align closely with croup, making Parainfluenza the most likely diagnosis.
  • Other Likely Diagnoses

    • Adenovirus infection: Adenoviruses can cause a range of respiratory symptoms, including sore throat, cough, and fever. While the barking cough is more characteristic of Parainfluenza, adenovirus infections can sometimes present with similar symptoms.
    • Influenza: Influenza can cause fever, sore throat, and cough, but the barking cough and hoarseness are less typical. However, influenza should be considered, especially during flu season.
    • Rhinovirus infection: Rhinoviruses are a common cause of the common cold, which can include symptoms like sore throat, cough, and runny nose. While the symptoms can overlap, the severity and specific characteristics of the patient's cough and voice changes make this less likely.
  • Do Not Miss Diagnoses

    • Respiratory syncytial infection (RSV): Although RSV is more commonly associated with severe illness in younger children and older adults, it can cause significant respiratory disease in anyone. Given the potential severity, especially if the patient has underlying health conditions, RSV should not be missed.
    • Bacterial tracheitis: This is a rare but serious condition that can present with similar symptoms, including a barking cough and significant respiratory distress. It requires prompt diagnosis and treatment with antibiotics.
  • Rare Diagnoses

    • Diphtheria: Although rare in areas with high vaccination coverage, diphtheria can cause a severe respiratory illness with a characteristic barking cough and hoarseness due to a pseudomembrane covering the tonsils and throat.
    • Other viral infections: There are many other viruses that can cause respiratory symptoms, but they are less likely given the specific combination of symptoms presented by the patient.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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