Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 16, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Multiple Inguinal Lymphadenopathies with Skin Lesions and Warm Sensation

Single Most Likely Diagnosis

  • Lymphogranuloma Venereum (LGV): This is a sexually transmitted infection caused by Chlamydia trachomatis, which can lead to inguinal lymphadenopathy, often accompanied by skin lesions and systemic symptoms such as fever, which might cause a warm sensation.

Other Likely Diagnoses

  • Cat Scratch Disease: Caused by Bartonella henselae, transmitted through cat scratches or bites, leading to lymphadenopathy, which can be accompanied by a papule or pustule at the site of the scratch.
  • Tuberculosis: Can cause lymphadenopathy and skin lesions, especially in immunocompromised individuals or those from endemic areas. The skin lesions can be accompanied by systemic symptoms like fever, causing a warm sensation.
  • Syphilis: A sexually transmitted infection that can cause lymphadenopathy and skin lesions (chancre in primary syphilis), which might be accompanied by a warm sensation due to inflammation.

Do Not Miss Diagnoses

  • Malignant Lymphoma: Although less common, lymphadenopathy can be a presenting feature of lymphoma. Skin lesions and systemic symptoms like fever (causing a warm sensation) can also occur, making it crucial not to miss this diagnosis due to its severe implications.
  • HIV Infection: Can present with lymphadenopathy and skin lesions (due to opportunistic infections or as part of the acute retroviral syndrome), along with systemic symptoms like fever, which might cause a warm sensation.

Rare Diagnoses

  • Kikuchi-Fujimoto Disease: A rare, self-limiting condition that causes lymphadenopathy, often accompanied by fever and night sweats, which could contribute to a warm sensation. Skin lesions are less common but can occur.
  • Whipple's Disease: A rare, systemic bacterial infection that can cause lymphadenopathy, skin lesions, and systemic symptoms including fever, which might cause a warm sensation. It's more common in immunocompromised individuals.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.