What supplies are needed for a rapid sequence intubation (RSI)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 17, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Essential Supplies for Rapid Sequence Intubation (RSI)

For a successful rapid sequence intubation, you must have a standardized set of equipment and medications that includes laryngoscopes, endotracheal tubes, neuromuscular blocking agents, sedative-hypnotic medications, and monitoring equipment. 1, 2

Airway Equipment

Basic Airway Equipment

  • Video laryngoscope with disposable blades (preferred) or direct laryngoscope with standard and short handles, metallic blades of different sizes 1
  • Endotracheal tubes:
    • Uncuffed (2.5,3.0,3.5,4.0,4.5.0,5.5, and 6.0 mm)
    • Cuffed (6.5,7.0,7.5,8.0, and 9.0 mm) 1
  • Stylets (malleable material to shape endotracheal tubes) 1
  • Oropharyngeal airways (sizes 0-5) 1
  • Nasopharyngeal airways (12F through 30F) 1

Backup Airway Equipment

  • Supraglottic airway devices (e.g., laryngeal mask airways) 1
  • Disposable flexible video bronchoscope (if available) 1
  • Cricothyroidotomy kit for emergency surgical airway 1

Monitoring Equipment

  • Capnography device (essential to confirm correct endotracheal tube placement) 1
  • Pulse oximeter with sensors appropriate for patient size 1
  • Cardiorespiratory monitor 1
  • Blood pressure monitoring equipment 1

Medications

Induction Agents (Sedative-Hypnotics)

  • Etomidate (0.3 mg/kg) or ketamine (1-2 mg/kg) - preferred for hemodynamically unstable patients 2, 3
  • Alternative options: propofol, midazolam 2, 4

Neuromuscular Blocking Agents

  • Succinylcholine (1-1.5 mg/kg) - first-line when no contraindications exist 2, 5
  • Rocuronium (0.6-1.2 mg/kg) - alternative when succinylcholine is contraindicated 2, 5
  • Note: If using rocuronium, sugammadex should be immediately available in case of "cannot intubate/cannot oxygenate" scenario 1, 2

Premedications (Used Selectively)

  • Fentanyl (1-3 mcg/kg) - for blunting sympathetic response 3, 4
  • Lidocaine (1-1.5 mg/kg) - for patients with increased intracranial pressure 3, 4
  • Atropine - for pediatric patients to prevent bradycardia 4

Positioning and Preoxygenation Equipment

  • Equipment to facilitate head and torso inclined (semi-Fowler) position 1, 2
  • High-flow nasal oxygen (HFNO) device - especially for anticipated difficult laryngoscopy 1, 2
  • Non-invasive positive pressure ventilation (NIPPV) equipment - for severely hypoxemic patients 1, 2
  • Bag-valve-mask resuscitator with appropriate masks (neonatal through adult sizes) 1
  • Oxygen source with flow regulators 1

Additional Essential Equipment

  • Suction device with Yankauer and flexible suction catheters 1
  • Nasogastric tubes (for gastric decompression in high-risk patients) 1, 2
  • IV access equipment 1
  • Syringes and needles for medication administration 1
  • Difficult airway trolley with immediate access to all equipment 1

Organizational Considerations

  • Equipment should be organized in a standardized manner for quick access 1
  • Medications should be prepared in advance with appropriate dosing 1, 6
  • A checklist should be used to ensure all necessary equipment is present 1
  • Daily checks of difficult airway equipment should be performed 1

Common Pitfalls and Considerations

  • Inadequate preoxygenation increases risk of desaturation - ensure proper technique and consider medication-assisted preoxygenation for uncooperative patients 2
  • Failure to have backup airway equipment immediately available can lead to "cannot intubate/cannot oxygenate" scenarios 1
  • Inappropriate medication selection or dosing can cause hemodynamic instability - choose induction agents based on patient's clinical condition 2, 3
  • Lack of capnography to confirm tube placement is a significant safety risk 1
  • Having a standardized protocol reduces medication redosing and complications 6

Remember that RSI should be performed by experienced providers, and repeated intubation attempts should be minimized to reduce risk of complications 1. The equipment and medications must be sufficient as visualization and access may be suboptimal during emergency situations 1.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Rapid Sequence Intubation in Emergency Situations

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Rapid-sequence intubation and the role of the emergency department pharmacist.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2011

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.