What is the typical size of a Benzaclin (duac, clindamycin and benzoyl peroxide) tube?

Tube Size of BenzaClin (Clindamycin and Benzoyl Peroxide)

BenzaClin (clindamycin and benzoyl peroxide) topical gel is available in 25 gram, 35 gram (pump), 50 gram, and 50 gram (pump) tube sizes. 1

Available Sizes and Formulation Details

• BenzaClin comes in four specific sizes:

  • 25 grams (NDC 45802-509-01) 1
  • 35 grams pump dispenser (NDC 45802-510-03) 1
  • 50 grams tube (NDC 45802-507-02) 1
  • 50 grams pump dispenser (NDC 45802-507-04) 1

• Each size contains specific amounts of active ingredients that require reconstitution:

  • 25 gram size: 19.7g benzoyl peroxide gel, 0.3g clindamycin powder, requires 5 mL purified water 1
  • 35 gram pump: 27.6g benzoyl peroxide gel, 0.4g clindamycin powder, requires 7 mL purified water 1
  • 50 gram sizes: 39.4g benzoyl peroxide gel, 0.6g clindamycin powder, requires 10 mL purified water 1

Clinical Context and Usage

• BenzaClin is a combination topical medication containing 1% clindamycin and 5% benzoyl peroxide for the treatment of inflammatory and noninflammatory acne vulgaris lesions 2

• The medication is typically used twice daily, or as directed by a physician, for the treatment of mild to moderately severe acne 2

• After reconstitution, the product can be stored at room temperature up to 25°C (77°F) for 3 months 1

Practical Considerations

• The pump dispensers (35g and 50g sizes) offer convenience for consistent dosing and may be preferred for longer-term use 1

• For comparison, other topical acne treatments have different standard sizes:

  • Ingenol mebutate comes in 2-3 single-application tubes 3
  • 5-Fluorouracil 5% typically comes in 40g tubes 3
  • Imiquimod 5% is available in 12-24 sachets 3

• BenzaClin has a fairly rapid onset of action, with acne improvement usually recorded within 2-4 weeks of starting treatment 2

• The combination of clindamycin and benzoyl peroxide helps prevent bacterial resistance that might occur with clindamycin alone 2