What is the recommended dosage of ibuprofen (nonsteroidal anti-inflammatory drug (NSAID)) for fever in a pediatric patient (5 years old)?

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Ibuprofen Dosage for Fever in a 5-Year-Old Child

The recommended dosage of ibuprofen for fever in a 5-year-old child is 10 mg/kg every 8 hours. 1

Dosing Guidelines

  • Ibuprofen should be dosed at 10 mg/kg per dose, administered every 8 hours for fever management in children 1, 2
  • For a 5-year-old child, oral ibuprofen is the preferred route of administration as it provides reliable absorption compared to rectal administration 3
  • The maximum daily dose should not exceed 30-40 mg/kg/day (divided into 3-4 doses) 3
  • The antipyretic effect typically peaks at 3-4 hours after administration 2

Administration Considerations

  • Ibuprofen suspension/liquid formulation is appropriate for children of this age 4
  • Administer with food or milk to reduce potential gastrointestinal irritation 2
  • Ensure proper hydration of the child while using ibuprofen to prevent potential renal adverse effects 3

Efficacy

  • At 10 mg/kg dosing, ibuprofen demonstrates superior fever reduction compared to lower doses (5 mg/kg) 5, 4
  • Clinical studies show that 10 mg/kg of ibuprofen is as effective as or more effective than 15 mg/kg of acetaminophen for fever reduction 5, 4
  • The relationship between dose and response is linear over the range of 5-10 mg/kg 2

Safety Considerations

  • Short-term use of ibuprofen at recommended doses is considered safe in children over 3 months of age 3
  • Ibuprofen is generally better tolerated by children than adults 2
  • Monitor for potential side effects including gastrointestinal discomfort, although these are uncommon at recommended doses 5
  • Avoid use if the child is dehydrated or has renal impairment 3

Common Pitfalls to Avoid

  • Underdosing (using less than 10 mg/kg) may result in inadequate fever control, especially for temperatures above 102.5°F 4
  • Exceeding the maximum daily dose of 40 mg/kg/day can increase risk of adverse effects 3
  • Using the rectal route in young children should be avoided due to erratic absorption 3
  • Failing to maintain adequate hydration during fever management with ibuprofen 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

A general overview of the use of ibuprofen in paediatrics.

International journal of clinical practice. Supplement, 2003

Research

Ibuprofen, acetaminophen, and placebo treatment of febrile children.

Clinical pharmacology and therapeutics, 1989

Research

Comparison of multidose ibuprofen and acetaminophen therapy in febrile children.

American journal of diseases of children (1960), 1992

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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