Recommended Dosing of Erceflora (Bacillus clausii) for Treating Diarrhea
For treating diarrhea, Bacillus clausii (Erceflora) should be administered at a dosage of 4 billion CFU/day for children and 6 billion CFU/day for adolescents and adults, typically for 5-7 days. 1, 2
Dosing by Age Group
Children (6 months to 5 years)
- One mini bottle (2 billion spores/5mL) twice daily (morning and evening) for 5-7 days 3, 4
- For persistent diarrhea cases, higher dosages of 4-6 bottles per day (8-12 billion CFU) have shown improved efficacy 2
Adolescents and Adults
- One to two mini bottles (2 billion spores/5mL per bottle) 2-3 times daily for 5-7 days, for a total of 6 billion CFU/day 1
Administration Guidelines
- Administer Bacillus clausii as an adjunct to standard rehydration therapy 3, 4
- Can be given with or without food 4
- For infants and young children, the contents can be mixed with water, milk, or juice at room temperature 4
- Do not mix with hot beverages or foods as high temperatures may inactivate the probiotic spores 1
Clinical Evidence and Efficacy
- Bacillus clausii has been shown to reduce the duration of diarrhea by approximately 2 days compared to standard treatment alone 2
- Studies demonstrate significant reduction in stool frequency from 5.2 ± 2.0 stools at baseline to 1.2 ± 0.6 stools at treatment end 4
- Improvement in stool consistency is typically observed within 3-4 days of treatment initiation 5
- In more than half of patients (52.6%), diarrhea resolves within the first 3 days of treatment 4
Important Considerations
- Bacillus clausii is most effective when started early in the course of diarrhea, preferably within the first 48 hours 3
- Concurrent use with antibiotics is acceptable as Bacillus clausii strains are resistant to most commonly used antibiotics 1
- Probiotic preparations may be offered to reduce symptom severity and duration in immunocompetent adults and children with infectious or antimicrobial-associated diarrhea 6
- The effectiveness of probiotics is strain-specific and dose-dependent 6
Cautions and Contraindications
- Avoid use in patients with known hypersensitivity to Bacillus clausii or excipients in the formulation 3
- While probiotics are generally considered safe, they should be used with caution in severely immunocompromised patients 6
- Probiotics should not be considered a substitute for proper rehydration therapy, which remains the cornerstone of diarrhea management 6
Monitoring Response
- Monitor for reduction in stool frequency and improvement in stool consistency 4, 5
- If no improvement is observed after 3 days of treatment, reassessment of the underlying cause of diarrhea is recommended 6
- For persistent symptoms beyond 14 days, consider non-infectious causes including lactose intolerance, inflammatory bowel disease, or irritable bowel syndrome 6