From the FDA Drug Label
In uncomplicated urinary tract infections, skin and skin-structure infections, disseminated gonococcal infections, and uncomplicated pneumonia, a 750 mg dose every 8 hours is recommended. The recommended dose and frequency of Cefuroxime (Ceftin) for the treatment of a Urinary Tract Infection (UTI) is 750 mg every 8 hours.
- The duration of treatment is usually for 5 to 10 days.
- In cases of impaired renal function, the dosage should be adjusted based on the degree of renal impairment and the susceptibility of the causative organism 1.
From the Research
Cefuroxime (Ceftin) is recommended for urinary tract infections (UTIs) at a dose of 250-500 mg taken orally twice daily for 7-10 days, with 250 mg twice daily often sufficient for uncomplicated UTIs 2. The medication should be taken with food to enhance absorption and reduce stomach upset. It's essential to complete the entire prescribed course even if symptoms improve before finishing the medication. Ceftin works by inhibiting bacterial cell wall synthesis, effectively killing the bacteria causing the infection. Patients should drink plenty of water while taking this medication to help flush bacteria from the urinary tract. Some key points to consider when prescribing Cefuroxime for UTIs include:
- The dose and duration of treatment may vary depending on the severity and complexity of the infection
- Common side effects may include diarrhea, nausea, and headache
- If a patient has a penicillin allergy, it's crucial to inform the healthcare provider as there is potential for cross-reactivity
- Improvement in symptoms should occur within 1-2 days, but patients should contact their healthcare provider if symptoms worsen or don't improve after 3 days
- A study from 2023 found that twice-daily dosing of cephalexin, another cephalosporin antibiotic, was as effective as four-times-daily dosing for uncomplicated UTIs, which may support the use of twice-daily dosing for Cefuroxime as well 3. However, the most recent and highest quality study specifically addressing Cefuroxime dosing for UTIs is from 1989, which found that a single daily dose of 250 mg for ten days was effective in treating acute uncomplicated UTIs 2. It's also important to note that the 2014 study found that β-lactam agents, including Cefuroxime, are not as effective as empirical first-line therapies for uncomplicated cystitis, and that fluoroquinolones should be reserved for more invasive infections 4. Overall, the recommended dose and frequency of Cefuroxime for UTIs should be based on the most recent and highest quality evidence available, taking into account the severity and complexity of the infection, as well as potential side effects and interactions.