Is creatine (phosphocreatine) effective for osteoporosis prevention?

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Last updated: March 25, 2025View editorial policy

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From the Research

Creatine supplementation is not a recommended first-line treatment for osteoporosis prevention, and its effectiveness for this purpose is still emerging and not well-established. The most recent and highest quality study, 1, emphasizes the importance of established approaches like calcium and vitamin D supplementation, weight-bearing exercise, and prescription medications when indicated for osteoporosis prevention. While creatine may have potential benefits for bone health, particularly when combined with resistance exercise, the evidence is not strong enough to support its use as a primary intervention for osteoporosis prevention.

Key points to consider:

  • Established approaches for osteoporosis prevention include calcium (1000-1200mg daily) and vitamin D (800-1000 IU daily) supplementation, weight-bearing exercise, and prescription medications when indicated 1.
  • Creatine supplementation may be considered as part of a comprehensive bone health strategy, but its effectiveness for osteoporosis prevention is still emerging and not well-established 1.
  • Resistance exercise, which can be enhanced by creatine supplementation, is an important component of osteoporosis prevention, as it helps maintain muscle mass and bone density 2.
  • People with kidney problems should consult their doctor before taking creatine, as it may have adverse effects on kidney function 1.

In terms of specific recommendations, the following can be considered:

  • Adults with a high risk of osteoporosis should consult their doctor about established approaches for prevention, including calcium and vitamin D supplementation, weight-bearing exercise, and prescription medications when indicated 1.
  • Creatine supplementation may be considered for individuals who are already engaging in resistance exercise and have a high risk of osteoporosis, but its use should be monitored and adjusted as needed to minimize potential side effects 1.
  • A comprehensive bone health strategy should include a combination of established approaches, lifestyle modifications, and potentially creatine supplementation, under the guidance of a healthcare professional 1.

References

Research

The clinician's guide to prevention and treatment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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