From the Research
No, PCP (phencyclidine) is not poorly absorbed. PCP is actually well-absorbed through multiple routes of administration including oral ingestion, inhalation, smoking, and injection. The drug is highly lipophilic (fat-soluble), which allows it to cross cell membranes easily, including the blood-brain barrier. This efficient absorption contributes to PCP's rapid onset of effects, typically within minutes when smoked or injected and within 30-60 minutes when taken orally. The lipophilic nature of PCP also means it can accumulate in fatty tissues of the body, leading to a prolonged elimination half-life of approximately 21-24 hours in most individuals. This extended presence in the body explains why PCP intoxication can last much longer than many other drugs of abuse, sometimes persisting for 24-48 hours or more, and why users may experience recurrent symptoms as the drug is slowly released from fat stores.
Some key points to consider when evaluating PCP absorption include:
- The ability of PCP to alter perception and cause hallucinations, delirium, and disorientation 1
- The potential for PCP to cause serious neurological and cardiovascular complications, particularly at high doses 1
- The importance of supportive psychological and medical measures in treating PCP intoxication, as well as the potential for acidification of the urine to increase PCP clearance 1
- The use of gas chromatography-mass spectrometry (GC-MS) for quantitation of PCP in urine and blood 2
Overall, the evidence suggests that PCP is well-absorbed and can have significant effects on the body, particularly in terms of its ability to alter perception and cause prolonged intoxication. The most recent and highest quality study, published in 2010, supports the idea that PCP is well-absorbed and can be quantitated in urine and blood using GC-MS 2. This study provides a reliable method for detecting and quantifying PCP, which is essential for forensic analysis and clinical diagnosis. In terms of morbidity, mortality, and quality of life, it is essential to prioritize caution and careful management when dealing with PCP intoxication, given its potential for serious complications and prolonged effects.