Bromfed (Brompheniramine and Pseudoephedrine) Pediatric Dosing
The recommended dosage of Bromfed (brompheniramine and pseudoephedrine) for pediatric patients is age-based: children 6-12 years should receive 5 mL (1 teaspoonful) every 4 hours, children 2-6 years should receive 2.5 mL (½ teaspoonful) every 4 hours, and infants 6 months to 2 years require physician-established dosing, with no more than 6 doses in a 24-hour period. 1
Age-Based Dosing Recommendations
- Adults and children 12 years and older: 10 mL (2 teaspoonfuls) every 4 hours 1
- Children 6 to under 12 years: 5 mL (1 teaspoonful) every 4 hours 1
- Children 2 to under 6 years: 2.5 mL (½ teaspoonful) every 4 hours 1
- Infants 6 months to under 2 years: Dosage to be established by a physician 1
- Maximum frequency: Do not exceed 6 doses during a 24-hour period 1
Clinical Considerations
Pharmacokinetic Considerations
- Pediatric patients experience unique differences from adults in pharmacokinetic parameters and require individualized dosing based on age, size, and organ maturity 2
- For brompheniramine specifically, studies have shown that while Cmax (maximum concentration) is similar across age groups, it tends to occur earlier in younger children 3
- The AUC (area under the curve) is approximately 15-30% higher in older age groups, indicating potential differences in drug exposure 3
Safety Considerations
- Sedation is the most common adverse effect reported with brompheniramine and appears to be more prevalent in children 2-5 years old 3
- The half-life of brompheniramine is approximately 15 hours across pediatric age groups, which supports the recommended dosing interval 3
Administration Tips
- The syrup formulation facilitates administration to children who may have difficulty swallowing tablets 4
- Ensure accurate measurement using appropriate measuring devices (not household spoons) to prevent dosing errors 2
Special Populations
- For children with renal impairment, consider dose reduction as antihistamines may have prolonged effects in these patients 4
- Avoid use in children with severe hepatic impairment due to potentially increased sedating effects 4
Common Pitfalls to Avoid
- Avoid calculating pediatric doses as simple fractions of adult doses without considering age-specific pharmacokinetics 5
- Do not exceed the maximum recommended frequency of 6 doses in 24 hours, as this may lead to adverse effects 1
- Be cautious about sedative effects, especially when combining with other medications that may cause central nervous system depression 3