Recommended Dosage of Levocetirizine and Montelukast for a 1-Year-Old
For a 1-year-old child, the recommended dosage is levocetirizine 0.125 mg/kg twice daily and montelukast 4 mg once daily in the evening.
Levocetirizine Dosing
- For children aged 1-2 years, levocetirizine should be administered at 0.125 mg/kg twice daily 1
- This dosage has been shown to provide adequate plasma concentrations with a peak level of approximately 286 ng/ml after one hour 1
- The elimination half-life in this age group is about 4.1 hours, with good safety profile demonstrated in clinical studies 1
- Long-term safety of levocetirizine at this dosage has been confirmed in young atopic children in an 18-month study 2
- The medication demonstrates excellent inhibition of histamine-induced wheal and flare response at this dosage, with median inhibition of 100% for wheal and 99.6% for flare 1
Montelukast Dosing
- Although specific dosing for 1-year-olds is not explicitly mentioned in the provided guidelines, the closest age-appropriate dosing would be 4 mg once daily in the evening 3
- Montelukast is typically dosed according to age groups, with 4 mg being the standard pediatric dose for young children 3
- For older children (6-14 years), a 5 mg chewable tablet is recommended based on pharmacokinetic studies 4
Combination Therapy Considerations
- The combination of levocetirizine and montelukast has shown superior efficacy compared to montelukast monotherapy in reducing nasal symptoms in children with allergic conditions 5
- When using these medications together, monitor for any potential side effects, although studies show the combination is generally well-tolerated 5
Safety Considerations
- Levocetirizine has demonstrated a good safety profile in infants and children with allergic rhinitis or chronic urticaria 6
- In clinical studies, the incidence of treatment-emergent adverse events was similar between levocetirizine and placebo in young children 6
- Most adverse events are mild to moderate in intensity, with the most common being related to upper respiratory tract infections, transient gastroenteritis symptoms, or exacerbations of allergic diseases 2
- No significant changes in vital signs, ECG parameters, or laboratory values have been observed with levocetirizine use in young children 6
Administration Tips
- Levocetirizine is available as oral liquid drops, making it suitable for administration to young children 6
- Administer the medication at the same time each day to maintain consistent blood levels 1
- For montelukast, evening administration is preferred based on the medication's pharmacokinetic profile 4