From the Guidelines

Hypercalcemia should be treated with hydration, bisphosphonates, denosumab, steroids, and/or calcitonin.

Hydration is essential to help decrease calcium levels in the blood 1.
Bisphosphonates, such as zoledronic acid, pamidronate, and ibandronate, are effective in treating hypercalcemia, with zoledronic acid being the preferred choice 1.
Denosumab and steroids can also be used to treat hypercalcemia 1.
Calcitonin is another option for treating hypercalcemia 1.

Furosemide can be used in conjunction with hydration to help decrease calcium levels 1.
Orthopedic consultation should be obtained for impending or actual fractures in weight-bearing bones, bony compression of the spinal cord, or vertebral column instability 1.
Vertebroplasty or kyphoplasty should be considered for symptomatic vertebral compression fractures 1.

From the Research

The treatment of hypercalcemia depends on the underlying cause and severity of the condition.

For mild hypercalcemia, treatment may not be necessary, but monitoring of serum calcium levels and underlying cause is essential 2.
For symptomatic or severe hypercalcemia, initial therapy consists of hydration and intravenous bisphosphonates, such as zoledronic acid or pamidronate 2, 3, 4, 5, 6.
Glucocorticoids may be used as primary treatment when hypercalcemia is due to excessive intestinal calcium absorption (vitamin D intoxication, granulomatous disorders, some lymphomas) 2, 3, 6.
In patients with kidney failure, denosumab and dialysis may be indicated 2, 5.
Calcitonin can be used for short-term control of severe hypercalcemia, but its therapeutic efficacy is limited by lack of potency and tachyphylaxis 3, 4, 5, 6.
The bisphosphonates, such as pamidronate, are effective in inhibiting osteoclastic bone resorption and can be used to treat hypercalcemia 3, 4, 5, 6.
Treatment of the underlying cause, such as surgery for primary hyperparathyroidism or anti-tumor therapy, is essential for controlling chronic hypercalcemia 2, 3, 4, 5, 6.

Bisphosphonates: zoledronic acid, pamidronate, clodronate, ibandronate 3, 4, 5, 6
Calcitonin 3, 4, 5, 6
Glucocorticoids 2, 3, 6
Denosumab 2, 5
Gallium nitrate 4
Plicamycin (mithramycin) 3, 4
Loop diuretics 5, 6

Patients with mild to moderate hypercalcemia may be asymptomatic, and therapy should be directed at the primary disease as well as at preventing complications that could raise the level of serum calcium 3.
Efforts should be made to prevent volume contraction and prolonged bed rest in patients with hypercalcemia 3.
Sedatives and narcotic analgesics can raise serum calcium levels and should be used with caution in patients with hypercalcemia 3.