What is the treatment for postpartum mastitis?

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Last updated: October 22, 2025View editorial policy

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Treatment of Postpartum Mastitis

The first-line treatment for postpartum mastitis includes continued breastfeeding or milk expression from the affected breast, supportive measures such as NSAIDs and ice application for 1-2 days, followed by antibiotics effective against Staphylococcus aureus (such as dicloxacillin or cephalexin) if symptoms persist. 1, 2

Diagnosis and Clinical Presentation

  • Mastitis is diagnosed clinically based on symptoms including fever, malaise, focal breast tenderness, and overlying skin erythema or hyperpigmentation 1
  • Laboratory tests or imaging are typically not needed for initial diagnosis in straightforward cases 1
  • Approximately 10% of breastfeeding mothers in the United States develop mastitis, most commonly in the first 3 months postpartum 3, 1

Initial Management Approach

  • Continue breastfeeding or milk expression from the affected breast as this is essential for treatment 2
  • Begin with conservative measures for 1-2 days:
    • Nonsteroidal anti-inflammatory drugs for pain and inflammation 1
    • Ice application to reduce inflammation 1
    • Feed infant directly from the affected breast 1
    • Minimize excessive pumping as it may worsen the condition 1

Antibiotic Therapy

  • If no improvement after 1-2 days of conservative measures, initiate antibiotics 1
  • Choose antibiotics effective against Staphylococcus aureus:
    • First-line options: dicloxacillin or cephalexin 3
    • Consider coverage for methicillin-resistant S. aureus (MRSA) in areas with high prevalence 3
  • Milk cultures should be considered to guide antibiotic therapy in cases that don't respond to initial treatment 1

Management of Complications

  • Approximately 10% of mastitis cases progress to breast abscess 2
  • If abscess is suspected (persistent symptoms despite antibiotics), obtain breast ultrasound 1
  • Abscesses require drainage, either by surgical incision or needle aspiration 3
  • Breastfeeding can continue on the affected side as long as the infant's mouth does not contact purulent drainage 2
  • For worsening symptoms or concerns for sepsis, intravenous antibiotics and hospital admission may be required 1

Prevention Strategies

  • Optimize breastfeeding technique, including proper infant latch 3, 1
  • Encourage physiologic breastfeeding rather than pumping when possible 1
  • Avoid practices that may worsen the condition:
    • Excessive pumping to empty the breast 1
    • Aggressive breast massage 1
    • Excessive heat application 1

Important Considerations

  • Discontinuing breastfeeding during mastitis treatment can worsen the condition 2
  • Delaying treatment of non-responsive cases may lead to abscess formation 2
  • Consider consultation with a lactation specialist to optimize breastfeeding technique 3
  • Candida infection may develop as a complication of antibiotic therapy and should be treated appropriately if diagnosed 4

References

Research

Mastitis: Rapid Evidence Review.

American family physician, 2024

Guideline

Management of Lactational Mastitis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Management of mastitis in breastfeeding women.

American family physician, 2008

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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