From the Research
Dose of Methylprednisolone for Nausea and Vomiting
- The dose of methylprednisolone used to treat nausea and vomiting varies across studies.
- In one study, high-dose methylprednisolone (120 mg given i.v. and repeated after a 4-h interval) was used in combination with metoclopramide and alprazolam to control nausea and emesis induced by anthracycline-containing multiple-day chemotherapy 1.
- Another study used methylprednisolone (500 mg as the first dose and 250 mg for subsequent doses) as a single antiemetic medication against cisplatin-induced nausea and vomiting, but found it to be of limited value 2.
- A study comparing methylprednisolone sodium succinate with low-dose metoclopramide hydrochloride used 250 mg of methylprednisolone intravenously before chemotherapy 3.
- In a randomized, double-blind study, patients received either 250 mg of methylprednisolone or 10 mg of metoclopramide intravenously before chemotherapy 3.
- A study using methylprednisolone in combination with metoclopramide for cis-platinum-induced nausea and vomiting did not specify the dose of methylprednisolone used 4.
- In a prospective randomized trial, patients received methylprednisolone (125 mg) intramuscularly once a day in combination with metoclopramide or granisetron for delayed nausea and vomiting induced by cisplatin-based chemotherapy 5.