What are the treatment options for back pain?

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Last updated: October 23, 2025View editorial policy

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Treatment Options for Back Pain

For most patients with back pain, first-line treatment should include non-pharmacological self-care measures and acetaminophen or NSAIDs, with additional therapies added based on pain duration, severity, and response to initial treatment. 1, 2

Initial Management for Acute Back Pain (<4 weeks)

  • Self-care measures should be recommended as first-line treatment, including remaining active rather than resting in bed and applying heat via heating pads or heated blankets for short-term relief 1, 2
  • Acetaminophen should be considered as a first-line medication due to its favorable safety profile, though recent evidence suggests it may be less effective than previously thought for acute low back pain 1
  • NSAIDs are more effective than acetaminophen for pain relief but carry gastrointestinal, renovascular, and cardiovascular risks that should be carefully assessed before prescribing 1
  • Skeletal muscle relaxants such as cyclobenzaprine can be effective for short-term pain relief in acute back pain but cause sedation and should only be used for short periods (up to 2-3 weeks) 1, 3
  • For severe acute pain not responding to acetaminophen or NSAIDs, skeletal muscle relaxants may be added as adjunctive therapy 1, 3

Management for Subacute Back Pain (4-12 weeks)

  • Continue self-care measures and first-line medications (acetaminophen or NSAIDs) if providing benefit 1
  • Consider spinal manipulation administered by providers with appropriate training, which shows small to moderate short-term benefits 1, 4
  • Brief individualized educational interventions can reduce sick leave in workers with subacute back pain 1, 4
  • If pain persists despite these measures, consider intensive interdisciplinary rehabilitation 1, 4

Management for Chronic Back Pain (>12 weeks)

  • Non-pharmacological therapies with proven benefits should be considered, including:
    • Exercise therapy with individual tailoring, supervision, stretching, and strengthening 1, 4
    • Yoga, acupuncture, massage therapy, or spinal manipulation 1, 4
    • Cognitive-behavioral therapy or progressive relaxation 1, 4
  • For pharmacological management:
    • NSAIDs remain a first-line option but have smaller benefits for chronic back pain than previously observed 1
    • Duloxetine has been found effective for chronic low back pain and can be considered as a second-line option 1
    • Tramadol may be considered as a second-line therapy if NSAIDs are ineffective 1, 5
    • Opioids should only be considered if other treatments have failed and only if potential benefits outweigh risks, with careful discussion of known risks and realistic benefits 1, 6

Special Considerations

  • Medium-firm mattresses are preferred over firm mattresses for patients with chronic back pain 1, 2
  • For elderly patients, acetaminophen is the safest first-line medication option, with NSAIDs used at the lowest effective dose for the shortest period necessary due to increased risks 2, 6
  • Benzodiazepines have been found ineffective for radicular back pain and should be avoided 1
  • Systemic corticosteroids do not appear to be effective for back pain and are not recommended 1

Common Pitfalls to Avoid

  • Prolonged bed rest should be avoided as it can lead to deconditioning and potentially worsen symptoms 1, 4
  • Routine imaging for initial evaluation should not be performed unless there are red flags suggesting serious underlying conditions 1
  • Extended courses of medications should generally be reserved for patients clearly showing continued benefits without major adverse events 1, 3
  • Overreliance on muscle relaxants can lead to sedation and falls risk, particularly in elderly patients 2, 3
  • Recent evidence suggests acetaminophen may be ineffective for acute low back pain, so NSAIDs may be preferred if there are no contraindications 1, 7

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Safe Pain Management Options for Elderly Patients with Low Back Pain

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Treatment of Sciatic Nerve Pain

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Non-steroidal anti-inflammatory drugs for chronic low back pain.

The Cochrane database of systematic reviews, 2016

Research

Paracetamol for low back pain.

The Cochrane database of systematic reviews, 2016

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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