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Last updated: October 23, 2025View editorial policy

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Differential Diagnosis for Axillary Node Pain in Children

Single Most Likely Diagnosis

  • Cat scratch disease: This is a common cause of axillary lymphadenopathy in children, typically presenting with a history of cat scratch or exposure, followed by the development of a painful axillary lymph node.

Other Likely Diagnoses

  • Infectious mononucleosis: Caused by Epstein-Barr virus, it can lead to lymphadenopathy, including axillary nodes, along with fever, sore throat, and fatigue.
  • Streptococcal or staphylococcal infections: Bacterial infections such as impetigo, folliculitis, or abscesses in the arm or chest area can cause axillary lymphadenitis.
  • Viral upper respiratory infections: Common colds or flu can sometimes cause lymph node enlargement and pain, including in the axilla.

Do Not Miss Diagnoses

  • Lymphoma: Although rare, lymphomas such as Hodgkin lymphoma or non-Hodgkin lymphoma can present with lymphadenopathy, including axillary nodes, and are critical to diagnose early.
  • Tuberculosis: TB can cause lymphadenitis, and axillary nodes can be involved. It's particularly important to consider in children who have been exposed to TB or have risk factors.
  • Sarcoma (e.g., rhabdomyosarcoma): Soft tissue sarcomas can present with a mass or pain in the axillary region, including involvement of the lymph nodes.

Rare Diagnoses

  • Leukemia: Certain types of leukemia can cause lymphadenopathy, but this is less common as a presenting symptom compared to other signs like anemia, thrombocytopenia, or blasts on a blood smear.
  • Kawasaki disease: This condition can cause lymphadenopathy, but it's more commonly associated with other symptoms like fever, rash, conjunctivitis, and changes to the lips and oral cavity.
  • Brucellosis: A zoonotic infection that can cause lymphadenitis among other symptoms, but it's rare and typically associated with specific exposures (e.g., to infected animals or their products).

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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