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Last updated: October 24, 2025View editorial policy

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Differential Diagnosis for Travel to Central America with Fevers and Myalgias

Single Most Likely Diagnosis

  • Dengue Fever: This is a common illness in Central America, transmitted by mosquitoes, and characterized by high fever, severe headache, pain behind the eyes, joint and muscle pain, rash, and mild bleeding.

Other Likely Diagnoses

  • Zika Virus: Similar to dengue, Zika is transmitted by mosquitoes and can cause fever, rash, joint pain, and conjunctivitis. Its presence in Central America makes it a likely consideration.
  • Chikungunya: Another mosquito-borne illness prevalent in Central America, characterized by sudden onset of fever and severe joint pain.
  • Influenza: While not exclusive to Central America, influenza can cause similar symptoms and should be considered, especially during flu season.

Do Not Miss Diagnoses

  • Malaria: Although less common in some parts of Central America, malaria is a potentially deadly disease transmitted by mosquitoes. It causes periodic fevers, chills, and flu-like symptoms.
  • Leptospirosis: This bacterial infection can be contracted through water exposure and causes fever, headache, and muscle aches. It's crucial to consider in travelers who have been swimming or wading in freshwater.
  • Typhoid Fever: Caused by Salmonella Typhi, this illness is more common in areas with poor sanitation. It presents with prolonged fever, headache, nausea, loss of appetite, and abdominal pain.

Rare Diagnoses

  • Venezuelan Equine Encephalitis (VEE): A viral disease transmitted by mosquitoes, which can cause severe symptoms including fever, headache, and encephalitis.
  • Hantavirus: While more commonly associated with the southwestern United States, some strains of hantavirus are found in Central America. It can cause hantavirus pulmonary syndrome (HPS), a severe and sometimes fatal respiratory disease.
  • Rickettsial Diseases: Such as Rocky Mountain spotted fever, which can be found in Central America and causes fever, headache, and rash.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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