Polymyxin B and Trimethoprim Ophthalmic Solution Supply Information
Polymyxin B and trimethoprim ophthalmic solution is supplied as a sterile solution in 10 mL plastic dropper bottles with NDC 60758-908-10 or NDC 63187-193-10. 1, 2
Storage Requirements
- Store at 15°-25°C (59°-77°F) or 20°-25°C (68°-77°F), depending on manufacturer 1, 2
- Protect from light 1, 2
- Keep out of reach of children 2
Formulation Details
- Contains polymyxin B sulfate and trimethoprim as active ingredients 1, 2
- Supplied in opaque white low density polyethylene ophthalmic dispenser bottles with white high impact polystyrene caps 1
- Available by prescription only (Rx only) 1
Clinical Applications
- Used for treatment of surface ocular bacterial infections 3
- Effective against both gram-positive and gram-negative pathogens, making it suitable for empiric therapy of acute bacterial conjunctivitis 4
- Commonly used in the management of bacterial keratitis, particularly for infections caused by Staphylococcus aureus and Pseudomonas aeruginosa 5
- Also used as prophylaxis in patients with Boston type 1 keratoprosthesis to prevent vision-threatening endophthalmitis 6
Efficacy
- Clinical studies have demonstrated high efficacy rates, with 95% of infected eyes showing improvement or cure within 7 days 4
- Overall efficacy rated as excellent or good in 96% of cases in pediatric patients with acute bacterial conjunctivitis 4
- Combination of trimethoprim with polymyxin B has been shown to be safe and highly efficacious for the treatment of surface ocular bacterial infections 3
Patient Comfort and Tolerability
- Patients or caregivers report high comfort levels with this medication (62% very comfortable, 27% moderately comfortable) 4
- Adverse events are typically transient and of mild-to-moderate intensity 4
- Fewer adverse experiences compared to some other ophthalmic antimicrobial combinations 3
Distribution Information
- Distributed by various manufacturers including Allergan USA, Inc. and Akorn, Inc. 1, 2
- For more information, patients can contact manufacturer helplines (e.g., 1-800-678-1605 for Allergan products) 1
This ophthalmic solution provides an effective topical treatment option for ocular surface infections with broad-spectrum coverage and good patient tolerability.