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Last updated: October 25, 2025View editorial policy

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Differential Diagnosis for Edematous Penis

  • Single most likely diagnosis
    • Phimosis: This condition, where the foreskin cannot be fully retracted over the glans penis, can lead to edema due to poor hygiene, irritation, or infection. It's a common issue that could explain penile edema, especially in uncircumcised males.
  • Other Likely diagnoses
    • Balanitis: An inflammation of the glans penis, often due to infection or poor hygiene, which can cause swelling and edema.
    • Contact dermatitis: An allergic reaction or irritation from soaps, condoms, or other products can lead to edematous reactions on the penis.
    • Cellulitis: A bacterial skin infection that can cause redness, swelling, and warmth, including in the genital area.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Necrotizing fasciitis: A severe, life-threatening infection that can cause swelling, pain, and necrosis of the skin and underlying tissues. Early recognition is crucial for survival.
    • Penile fracture: Although not typically presenting with edema alone, any trauma to the penis can cause swelling and should be considered, especially if there's a history of trauma.
    • Malignancy: Certain cancers, like penile cancer, can present with swelling or lesions. While rare, missing a diagnosis of cancer can have severe consequences.
  • Rare diagnoses
    • Lymphogranuloma venereum (LGV): A sexually transmitted infection caused by certain types of Chlamydia trachomatis, which can lead to swelling and other symptoms in the genital area.
    • Filarial infections: Infections like lymphatic filariasis can cause severe swelling (elephantiasis) in various parts of the body, including the genitals, though this is more common in endemic areas.
    • Fabry disease: A rare genetic disorder that can lead to the accumulation of a particular type of fat in the body's cells, affecting many parts of the body and potentially causing edema, among other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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