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Last updated: October 27, 2025View editorial policy

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Differential Diagnosis for Active Bleeding Breast Mass

  • Single most likely diagnosis
    • Breast cancer with hemorrhagic necrosis: This is a common cause of a bleeding breast mass, especially in older women or those with a history of breast cancer. The tumor can outgrow its blood supply, leading to necrosis and bleeding.
  • Other Likely diagnoses
    • Fibroadenoma with infarction: Fibroadenomas are common benign breast tumors that can undergo infarction, leading to bleeding and necrosis, especially during pregnancy or breastfeeding.
    • Breast cyst: Simple breast cysts can rupture and cause bleeding, although this is less common.
    • Hematoma: Trauma to the breast can cause a hematoma, which can present as a bleeding breast mass.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Angiosarcoma: A rare and aggressive malignant tumor that can cause bleeding due to its vascular nature. It is essential to consider this diagnosis to ensure prompt treatment.
    • Pseudoangiomatous stromal hyperplasia (PASH) with hemorrhage: PASH is a rare benign condition that can mimic angiosarcoma and cause bleeding.
    • Metastasis to the breast: Although rare, metastatic disease to the breast from other primary sites (e.g., melanoma, lung, or renal cell carcinoma) can cause a bleeding breast mass.
  • Rare diagnoses
    • Hemangioma: A benign vascular tumor that can cause bleeding, although this is rare in the breast.
    • Lymphangioma: A rare benign tumor of the lymphatic vessels that can cause bleeding.
    • Breast lymphoma: A rare malignant condition that can cause a bleeding breast mass.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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