Initial Treatment for Piriformis Syndrome
Physical therapy is strongly recommended as the initial treatment for piriformis syndrome, focusing on supervised exercise programs rather than passive modalities. 1
First-Line Treatment Approach
Physical therapy interventions should include:
Home exercise program should be prescribed after initial instruction by a physical therapist 1
Correct underlying biomechanical factors:
Physical therapy may be augmented with:
Second-Line Treatment Options
NSAIDs may be used for symptomatic relief of pain when first-line treatments are insufficient 1, 2
Local injections should be considered if pain persists despite physical therapy:
- Glucocorticoid injections are conditionally recommended for persistent piriformis-related pain 1
- Local anesthetic injections may provide diagnostic and therapeutic benefits 4
- Botulinum toxin type A injections have shown effectiveness for piriformis pain lasting 8-12 weeks 1
- Image guidance is recommended to ensure accurate placement of injections 1
Adjunctive Approaches
Transcutaneous electrical nerve stimulation (TENS) can be used as part of a multimodal approach to pain management 1
Cognitive behavioral therapy and relaxation techniques may benefit patients with chronic myofascial pain 2
Topical treatments including lidocaine patches, capsaicin, and diclofenac patches may provide localized relief 2
Treatment Algorithm
Begin with 6-12 weeks of conservative management:
- Physical therapy with focus on piriformis stretching and strengthening
- Home exercise program
- Correction of biomechanical factors
If inadequate response after 6-12 weeks, add:
- NSAIDs for pain management
- Local injections (glucocorticoid or botulinum toxin)
For persistent symptoms beyond 3 months despite above treatments:
Common Pitfalls and Caveats
Piriformis syndrome is often underdiagnosed, comprising between 0.3-6% of all low back pain cases 5
The diagnosis is primarily clinical as no investigations have proven definitive 3
Surgical intervention should be reserved as a last resort, with endoscopic approaches preferred over open techniques due to higher success rates and fewer complications 5
Patients often have concurrent myofascial involvement of related muscles and lumbar facet syndromes that should be addressed 3
Avoid high-velocity spinal manipulation in patients with spinal fusion or advanced spinal osteoporosis 1