What is the relationship between hiccups and Thorazine (chlorpromazine)?

From the Guidelines

Thorazine (chlorpromazine) is an effective treatment for intractable hiccups, as evidenced by its use in clinical settings 1.

Treatment Overview

The relationship between hiccups and Thorazine (chlorpromazine) is rooted in the drug's ability to affect dopamine receptors in the brain, which helps regulate the hiccup reflex.

• The typical dosage for hiccups is 25-50 mg taken orally three to four times daily 1.
• For severe cases, intramuscular injection of 25-50 mg may be used 1.
• Treatment duration is usually short-term until hiccups resolve 1.

Side Effects and Precautions

While Thorazine can be effective, it's crucial to consider its side effects and use it cautiously, especially in certain patient populations.

• Side effects may include drowsiness, dizziness, dry mouth, blurred vision, and in rare cases, movement disorders 1.
• This medication should be used cautiously in elderly patients and those with cardiovascular disease, seizure disorders, or liver problems 1.

Clinical Considerations

Before prescribing Thorazine for hiccups, healthcare providers should consider simpler remedies and the patient's overall health status.

• Simpler remedies like holding your breath, drinking water, or using medications like baclofen or gabapentin might be attempted first 1.
• Always consult with a healthcare provider before using Thorazine for hiccups, as they can determine if it's appropriate for your specific situation 1.

From the Research

Relationship between Hiccups and Thorazine (Chlorpromazine)

• Hiccups can be caused by a variety of conditions, and drug therapy is often necessary for more intractable cases 2.
• Chlorpromazine, also known as Thorazine, is one of the most widely employed agents for the treatment of hiccups 2, 3.
• Chlorpromazine is the only Food and Drug Administration-approved agent specifically indicated for hiccups 3.
• However, chlorpromazine does not always provide favorable results, and other treatment options may be necessary 3, 4.
• Antidopaminergic agents, such as chlorpromazine and haloperidol, are preferred drugs used for the treatment of chronic hiccups 5.
• Despite its approval for treating hiccups, there is limited evidence to support the use of chlorpromazine over other pharmacologic treatments 4.

Efficacy and Safety of Chlorpromazine for Hiccups

• Chlorpromazine has been shown to be effective in treating hiccups in some cases, but its efficacy can vary depending on the individual patient and the underlying cause of the hiccups 2, 3, 6.
• The use of chlorpromazine for hiccups may be associated with adverse effects, and therapy selection should be specific to individual patients and their underlying comorbidities 4.
• Other pharmacologic treatment options, such as gabapentin, metoclopramide, and baclofen, may be effective in treating hiccups and may be considered as alternative or adjunctive therapies 3, 4.