From the Guidelines
The hormone used in the Kyleena Intrauterine Device (IUD) is levonorgestrel, a synthetic form of progesterone, as indicated in the study published in the American Journal of Obstetrics and Gynecology in 2019 1.
Key Characteristics of Kyleena IUD
- The Kyleena IUD contains 19.5 mg of levonorgestrel, which is released slowly over time.
- The failure rate of the Kyleena IUD is 0.1%, making it a highly effective form of contraception.
- The device is approved for use for up to 5 years, as stated in the study 1.
Mechanism of Action
- Levonorgestrel works by thickening cervical mucus to prevent sperm from reaching the egg.
- It also inhibits sperm movement and thins the uterine lining to prevent implantation.
- Sometimes, it may suppress ovulation, adding to its contraceptive effect.
Advantages of Kyleena IUD
- Unlike combination hormonal contraceptives, Kyleena does not contain estrogen, making it suitable for women who cannot use estrogen-based contraceatives.
- The localized delivery of the hormone results in lower systemic absorption compared to oral contraceptives, leading to fewer hormonal side effects for most users.
- Kyleena provides effective contraception for up to 5 years and can be removed at any time if pregnancy is desired, offering flexibility and control over reproductive health.
From the FDA Drug Label
Active ingredient Levonorgestrel, USP 1.5 mg The hormone used in the Kyleena (levonorgestrel) Intrauterine Device (IUD) is levonorgestrel, a form of progestin 2.
- The active ingredient is levonorgestrel.
- The hormone type is progestin.
From the Research
Hormone Used in Kyleena IUD
- The hormone used in the Kyleena (levonorgestrel) Intrauterine Device (IUD) is levonorgestrel 3, 4, 5, 6, 7.
Characteristics of Levonorgestrel in Kyleena IUD
- The Kyleena IUD contains 19.5mg of levonorgestrel 3, 5, 6.
- The levonorgestrel-releasing intrauterine system (LNG-IUS) provides a release rate of 20 microg/24 h of levonorgestrel 4.
- The hormone released from the intrauterine device causes some systemic changes, however local effects, such as glandular atrophy and stromal decidualization, in addition to foreign body reaction, are dominant 4.