From the FDA Drug Label
Description: Pure Vita Vitamin D3 (Cholecalciferol) and Vitamin K2 (Menatetrenone-MK4) work together to support bone helath, calcium absorption and heart health. The relationship between Vitamin K2 and cardiovascular disease (coronary heart disease) is that Vitamin K2 supports heart health.
- The drug label suggests a potential link between Vitamin K2 and heart health, implying a possible role in reducing the risk of cardiovascular disease. However, the label does not provide explicit information on the relationship between Vitamin K2 and coronary heart disease specifically. 1
From the Research
Vitamin K2 supplementation is a viable and promising option to improve cardiovascular outcomes by preventing calcium from depositing in arteries and promoting its incorporation into bones, as supported by the most recent and highest quality study 2. The relationship between Vitamin K2 and cardiovascular disease is complex, but research suggests that Vitamin K2 plays a crucial role in regulating calcium homeostasis, which is essential for maintaining cardiovascular health.
- Vitamin K2 activates proteins that regulate calcium distribution in the body, specifically matrix Gla protein, which prevents arterial calcification, and osteocalcin, which helps incorporate calcium into bone.
- This dual action may reduce arterial stiffness and plaque formation, ultimately decreasing the risk of cardiovascular disease.
- A daily intake of 100-200 mcg of vitamin K2 (particularly the MK-7 form) is generally recommended for cardiovascular health, and it can be obtained through supplements or foods like natto, certain cheeses, egg yolks, and organ meats.
- While research is promising, vitamin K2 should complement rather than replace conventional heart disease prevention strategies like maintaining healthy blood pressure, exercising regularly, eating a balanced diet, and taking prescribed medications.
- It is essential to consult a doctor before taking K2 supplements, especially if you are on blood thinners like warfarin, as they may interact 3. The evidence from the most recent study 2 suggests that vitamin K2 supplementation is associated with improved cardiovascular outcomes, and its effects on the cardiovascular system are mediated through the activation of anti-calcific proteins.
- The study found that vitamin K2 supplementation can modify systemic calcification and arterial stiffness, ultimately reducing cardiovascular mortality.
- Although the direct effects of vitamin K2 on delaying the progression of vascular and valvular calcification are still being investigated, prior reports suggest potential improved survival among cardiac patients with vitamin K2 supplementation.
- The affordability and FDA-proven safety of vitamin K2 supplementation make it a viable option for improving cardiovascular outcomes.