What is involved in a comprehensive physical exam?

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Last updated: October 29, 2025View editorial policy

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Components of a Comprehensive Physical Examination

A comprehensive physical examination should include a thorough history, complete physical assessment, and appropriate laboratory testing tailored to the patient's age, risk factors, and presenting concerns. 1

History Taking Components

  • Begin with a detailed medical history including current symptoms, past medical conditions, surgical history, medications, allergies, and previous therapies 1, 2
  • Document a comprehensive 3-generation family history to identify relatives with genetic conditions or patterns of disease 1
  • Obtain a complete social history including tobacco, alcohol, and substance use 2
  • Assess functional capacity, exercise habits, sleep patterns, and dietary habits 1
  • Document psychosocial factors including mental health history, stress levels, and social support systems 1
  • Review all current medications including prescription, over-the-counter, and supplements 1

Physical Examination Sequence

Vital Signs

  • Measure complete vital signs: height, weight, BMI, blood pressure, temperature, heart rate, respiratory rate, and oxygen saturation 1, 3
  • Consider orthostatic vital signs when indicated (blood pressure and pulse measurements lying, sitting, and standing) 1

General Assessment

  • Evaluate overall appearance, level of consciousness, and apparent distress 3
  • Assess body habitus, looking for evidence of wasting, obesity, or abnormal fat distribution 3

Head and Neck Examination

  • Inspect head for deformities, lesions, and symmetry 3
  • Examine eyes including visual acuity, extraocular movements, and fundoscopic examination 1
  • Assess ears for hearing acuity and examine ear canals and tympanic membranes 2
  • Examine nose and sinuses for patency and discharge 2
  • Inspect oral cavity including teeth, gums, tongue, and pharynx 2
  • Palpate thyroid and lymph nodes in the neck 1, 3

Cardiopulmonary Assessment

  • Auscultate lungs for breath sounds, crackles, wheezes, or rubs 3
  • Inspect chest wall for symmetry of movement and use of accessory muscles 3
  • Auscultate heart for rate, rhythm, and presence of murmurs, gallops, or rubs 3
  • Assess jugular venous pressure and carotid arteries 3

Abdominal Assessment

  • Inspect for distension, visible peristalsis, or pulsations 3
  • Auscultate for bowel sounds and bruits 3
  • Palpate for tenderness, masses, organomegaly, or pulsatile masses 3
  • Assess for rebound tenderness and guarding 2

Musculoskeletal Assessment

  • Evaluate range of motion of major joints 3
  • Test muscle strength in all extremities 3
  • Assess for joint deformities, swelling, or tenderness 3
  • Evaluate gait and balance 3

Neurological Assessment

  • Evaluate mental status and cognitive function 3
  • Assess cranial nerves 2
  • Test sensory function using light touch, pinprick, temperature perception, and vibration testing 3
  • Evaluate deep tendon reflexes 3
  • Assess coordination, gait, and balance 3

Skin Assessment

  • Inspect skin for integrity, color, moisture, temperature, and turgor 3
  • Identify any lesions, ulcerations, or wounds 3
  • Pay particular attention to high-risk areas such as pressure points 3

Special Considerations for Specific Populations

For Patients with Diabetes

  • Perform comprehensive foot examination including skin integrity assessment, foot deformity evaluation, neurological assessment with the 10-g monofilament, and vascular assessment 1, 3
  • Screen for complications including retinopathy, nephropathy, and neuropathy 1
  • Monitor blood pressure and lipid profiles more frequently 1

For Patients with Cardiovascular Risk

  • Include more detailed cardiovascular assessment with attention to peripheral pulses, bruits, and signs of heart failure 3
  • Consider ECG for baseline assessment 1

For Patients with Eating Disorders

  • Include detailed weight history, patterns of eating behaviors, and compensatory behaviors 1
  • Assess vital signs with attention to orthostatic changes 1
  • Perform comprehensive review of systems to identify complications 1

Laboratory and Diagnostic Testing

  • Basic laboratory testing should include complete blood count, comprehensive metabolic panel, lipid profile, and urinalysis for most adults 1, 2
  • Consider thyroid function tests, especially in patients with risk factors 1
  • For patients with diabetes, include A1C, lipid profile, liver function tests, and urinary albumin-to-creatinine ratio 1
  • ECG is recommended for patients with cardiovascular risk factors or symptoms 1
  • Additional testing should be guided by specific symptoms, risk factors, and findings on physical examination 2, 4

Documentation and Follow-Up Planning

  • Document all findings thoroughly, noting both normal and abnormal results 5
  • Create a clear follow-up plan with specific timeframes based on findings 2
  • Provide patient education on self-examination techniques when appropriate 1
  • Establish appropriate referrals to specialists based on findings 1

Common Pitfalls to Avoid

  • Failing to perform orthostatic vital sign measurements in appropriate patients 2
  • Relying solely on laboratory tests without thorough physical examination 4, 5
  • Overlooking the importance of the review of systems, which has been shown to have higher therapeutic yield (7%) than many routine laboratory tests 5
  • Neglecting to examine areas that may reveal important findings, such as the fundoscopic examination or comprehensive foot examination in diabetic patients 1, 3

Remember that the physical examination remains a valuable diagnostic tool that can often establish a diagnosis without the need for expensive or invasive testing 4, 5.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Comprehensive Physical Examination Approach

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Comprehensive Head-to-Toe Examination for Patients with Diabetes

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

The Outpatient Physical Examination.

The Medical clinics of North America, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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