Do stimulants cause misophonia?

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Last updated: March 27, 2025View editorial policy

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From the Guidelines

Stimulant medications can potentially worsen misophonia symptoms in some individuals, and the most recent evidence suggests that common stimulants like methylphenidate and amphetamine salts may increase sensitivity to trigger sounds due to their effects on the central nervous system 1.

Introduction to Stimulants and Misophonia

Stimulant medications are commonly used to treat attention-deficit/hyperactivity disorder (ADHD) and can have various effects on the brain and body. Misophonia, a condition characterized by strong emotional reactions to certain sounds, can be influenced by stimulant medications. The relationship between stimulants and misophonia is complex and varies significantly between individuals.

Effects of Stimulants on Misophonia

The effects of stimulants on misophonia can be attributed to their impact on the central nervous system. Stimulants like methylphenidate and amphetamine salts increase dopamine and norepinephrine levels in the brain, which can enhance focus and attention. However, this increase in neurotransmitter activity can also amplify sensory processing, making individuals more aware of and reactive to environmental sounds.

Managing Misophonia with Stimulant Treatment

If you're experiencing misophonia while taking stimulants, consider discussing with your healthcare provider about:

  • Adjusting your dosage
  • Trying a different stimulant formulation
  • Exploring non-stimulant alternatives like atomoxetine (Strattera) or guanfacine (Intuniv) Keeping a symptom journal tracking your misophonia triggers and intensity in relation to medication timing can help identify patterns and guide treatment adjustments.

Multidisciplinary Approach to Managing Misophonia

Managing misophonia alongside stimulant treatment often requires a multidisciplinary approach, including:

  • Sound therapy
  • Cognitive behavioral therapy
  • Environmental modifications This comprehensive approach can help individuals with misophonia better manage their symptoms and improve their quality of life.

From the Research

Misophonia and Stimulants

  • There is no direct evidence in the provided studies to suggest that stimulants cause misophonia 2, 3, 4, 5, 6.
  • The studies focus on the treatment of misophonia, including cognitive behavioral therapy 2, exposure therapy 3, β-blockers 4, and selective serotonin reuptake inhibitors like fluoxetine 6.
  • The etiology of misophonia is not explicitly discussed in relation to stimulants in the given studies.
  • Misophonia is described as a condition characterized by a negative reaction to specific sounds, often accompanied by intense anger, disgust, or other strong emotional responses 2, 3, 4, 5, 6.

Treatment of Misophonia

  • Cognitive behavioral therapy (CBT) has been shown to be effective in reducing misophonia symptoms in approximately half of the patients studied 2.
  • Exposure therapy is proposed as a potential treatment for misophonia, with considerations for developing hierarchies and example exposure exercises 3.
  • β-blockers, such as propranolol, have been used to successfully treat a patient with misophonia and misokinesia, suggesting a novel treatment approach 4.
  • Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to be effective in treating misophonia in a case report 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Exposure Therapy for Misophonia: Concepts and Procedures.

Journal of cognitive psychotherapy, 2021

Research

Misophonia: current perspectives.

Neuropsychiatric disease and treatment, 2015

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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