Ceftriaxone/Tazobactam Dosing for a 1-Month-Old Infant
For a 1-month-old infant, the recommended dose of ceftriaxone is 50 mg/kg/day given once daily or divided every 12-24 hours, with tazobactam typically administered in a fixed ratio with the beta-lactam component. 1, 2
Age-Specific Considerations
- For neonates with postnatal age >7 days (which includes a 1-month-old), the recommended dose of ceftriaxone is 50-75 mg/kg/day given every 24 hours 1
- Ceftriaxone should be administered intravenously by infusion over a period of 30 minutes in infants older than neonates 2
- For serious infections, the dose may be increased to 50-100 mg/kg/day, not exceeding 2 grams per day 2
Infection-Specific Considerations
- For serious infections other than meningitis, the recommended total daily dose is 50-75 mg/kg, given in divided doses every 12 hours 2
- For meningitis, a higher dose of 100 mg/kg/day (not exceeding 4 grams daily) is recommended 2
- For less severe infections, 50 mg/kg/day is typically sufficient 1
Administration Guidelines
- Intravenous doses should be administered over 30 minutes in infants 2
- Concentrations between 10 mg/kg/mL and 40 mg/kg/mL are recommended for IV administration 2
- For tazobactam component (when given as a combination), it is typically administered in a fixed ratio with the beta-lactam component 3
Important Precautions
- Ceftriaxone should not be used in hyperbilirubinemic neonates due to the risk of bilirubin encephalopathy 1, 2
- Do not use diluents containing calcium (such as Ringer's solution or Hartmann's solution) to reconstitute ceftriaxone as particulate formation can result 2
- Ceftriaxone is incompatible with vancomycin, amsacrine, aminoglycosides, and fluconazole in admixtures 2
Monitoring Recommendations
- Monitor for signs of adverse reactions including anaphylaxis (rare) 3
- Watch for complications related to intravenous lines including infiltration and infection 3
- Be aware of potential disruption of evolving microbiome and development of antimicrobial resistance 3
Duration of Therapy
- Generally, ceftriaxone therapy should be continued for at least 2 days after the signs and symptoms of infection have disappeared 2
- The usual duration of therapy is 4 to 14 days; in complicated infections, longer therapy may be required 2
While there are limited specific guidelines for the tazobactam component in a 1-month-old, when administered as a combination therapy with beta-lactams, it follows the dosing schedule of the primary antibiotic, with appropriate adjustments for the fixed ratio formulation 3.