Recommended Dosage of Avamys (Fluticasone Furoate) Nasal Spray for Allergic Rhinitis
For allergic rhinitis, Avamys (fluticasone furoate) nasal spray should be administered as 2 sprays per nostril once daily for adults and adolescents over 11 years, and 1-2 sprays per nostril once daily for children aged 2-11 years. 1, 2
Age-Specific Dosing Recommendations
- For adults and adolescents (>11 years): 2 sprays per nostril once daily (total daily dose of 110 μg) 1, 2
- For children aged 2-11 years: 1-2 sprays per nostril once daily 2
- Once symptoms are controlled, the dose may be reduced to the minimum effective dose for maintenance therapy 2
Administration Guidelines
- Shake the bottle prior to use 2
- Have the patient blow their nose before using the spray 2
- Keep the head in an upright position during administration 2
- Regular use rather than as-needed approach is recommended for optimal symptom control 2
- However, as-needed use can be considered after initial control is achieved, as it provides similar symptom control with approximately 50% less medication exposure 3
Efficacy and Onset of Action
- Fluticasone furoate has an onset of therapeutic effect between 3-12 hours after administration 2
- Optimal efficacy is reached within days to weeks of consistent use 2
- Intranasal corticosteroids like fluticasone furoate are considered the most effective medications for treating allergic rhinitis 4
- Once-daily dosing of fluticasone furoate is as effective as twice-daily dosing of other nasal corticosteroids 5
Safety Considerations
- Common side effects include epistaxis, headache, pharyngolaryngeal pain, nasal ulceration, back pain, pyrexia, and cough 1, 2
- Contraindicated in patients with a history of hypersensitivity to fluticasone furoate or any components of the formulation 1, 2
- Has a good safety profile in children with no significant effect on growth at recommended doses 4, 2
Alternative Treatment Options
- If fluticasone furoate is not tolerated, other intranasal corticosteroids like mometasone furoate or triamcinolone acetonide may be considered 4
- For patients who cannot tolerate intranasal corticosteroids, intranasal antihistamines like azelastine may be an alternative, though they may cause sedation 4
- Leukotriene receptor antagonists are not recommended as primary therapy for allergic rhinitis 1