What are the recommended droplet precautions for SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)?

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Last updated: October 31, 2025View editorial policy

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Recommended Droplet Precautions for SARS-CoV-2

For healthcare workers caring for patients with COVID-19, droplet precautions should include surgical/medical masks, eye protection, gowns, and gloves at minimum, with N95/FFP2 respirators required for aerosol-generating procedures. 1, 2

Personal Protective Equipment Requirements

For Non-Aerosol-Generating Procedures:

  • Surgical/medical masks are recommended for healthcare workers caring for non-ventilated COVID-19 patients 1
  • Complete PPE should include gloves, gown, and eye protection (face shield or safety goggles) in addition to masks 2
  • Patients should wear surgical facemasks to prevent droplet transmission 1, 2
  • A minimum physical separation zone of 2 meters (6 feet) should be maintained between workers whenever possible 1, 3

For Aerosol-Generating Procedures:

  • N95/FFP2 respirators or equivalent are required along with other PPE (gloves, gown, eye protection) 1, 2
  • Aerosol-generating procedures should be performed in negative pressure rooms when available 1, 2
  • Common aerosol-generating procedures include:
    • Endotracheal intubation
    • Bronchoscopy
    • Non-invasive ventilation
    • Cardiopulmonary resuscitation (before intubation)
    • Tracheostomy
    • Disconnection of ventilatory circuits 1, 2

Procedural Considerations

Airway Management:

  • Video-guided laryngoscopy is preferred over direct laryngoscopy when available 1
  • Endotracheal intubation should be performed by the most experienced healthcare worker to minimize attempts and risk of transmission 1
  • Pre-oxygenation should achieve an end-tidal expired oxygen concentration of >90% before airway interventions 1
  • Ensure adequate neuromuscular blockade before all airway interventions 1
  • Release positive pressure within the breathing circuit by opening the adjustable pressure-limiting valve before airway interventions 1

Oxygen Therapy:

  • The flow of oxygen should be kept to a minimum while maintaining adequate saturation 1, 2
  • Avoid humidified oxygen and nebulized drugs when possible 1
  • Consider placing a surgical mask over the patient's mouth during oxygen therapy 1

Room and Environmental Requirements

  • Aerosol-generating procedures should be performed in negative pressure rooms 1, 2
  • When negative pressure rooms are unavailable, ensure adequate ventilation with at least 160 L/s air changes per hour 1
  • Allow adequate time (>30 minutes) to elapse before the next procedure in the same room 1
  • Disinfect floors and surfaces of the procedure suite after each patient 1
  • Minimize the amount of equipment inside the room to what is absolutely essential 1

Special Considerations

Regional Anesthesia:

  • Regional anesthesia procedures are not considered aerosol-generating, and therefore droplet precautions are recommended as a minimum 1
  • Higher-level precautions may be appropriate when caring for patients under spinal anesthesia in certain situations 1

Thoracic Surgery:

  • Efforts should be made to minimize the number of staff present in theater for aerosol-generating procedures 1
  • Double-lumen tubes should only be open to the atmosphere after allowing release of positive pressure through a HEPA viral filter 1
  • Flexible bronchoscopes pose significant contamination risks and should be stored in a designated area during procedures 1

Common Pitfalls and Caveats

  • Do not assume that a surgical mask provides the same protection as an N95/FFP2 respirator during aerosol-generating procedures 2, 4
  • Staff should be fit-tested for each different type of respirator to ensure proper protection 2
  • When scarcity is not an issue, use of a fitted respirator is a reasonable option even for non-aerosol-generating procedures 1
  • Airborne precautions should be maintained for the appropriate duration based on room air exchanges after aerosol-generating procedures are completed 2
  • The effectiveness of masks depends on proper fit and consistent use - N95/KN95 respirators offer the highest level of personal protection 5

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

COVID-19 Infection Control Measures

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

COVID-19 Prevention and Control Measures

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Medical mask or N95 respirator: When and how to use?

Turkish journal of medical sciences, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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