What vaccines are recommended for a 16-year-old?

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Last updated: October 31, 2025View editorial policy

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Recommended Vaccines for a 16-Year-Old

A 16-year-old should receive the Tdap (tetanus, diphtheria, acellular pertussis) booster, meningococcal conjugate (MenACWY) vaccine, human papillomavirus (HPV) vaccine series, and meningococcal B vaccine, along with any catch-up vaccines they may have missed. 1

Core Recommended Vaccines

Tetanus, Diphtheria, and Acellular Pertussis (Tdap)

  • If not already received, a 16-year-old should get one dose of Tdap vaccine 1
  • This is a booster dose that should be administered if the adolescent has not received it previously at ages 11-12 years 1
  • Subsequent Td boosters should be administered every 10 years 1

Meningococcal Conjugate Vaccine (MenACWY)

  • A dose of MenACWY is recommended at age 16 years, even if the adolescent received a dose at age 11-12 years 1
  • This is particularly important for first-year college students aged ≤21 years who will be living in residence halls 1
  • The second dose provides continued protection during the period of increased risk through early adulthood 2, 3

Human Papillomavirus (HPV) Vaccine

  • If not already completed, the HPV vaccination series should be administered 1
  • For adolescents who start the series before age 15, a 2-dose schedule is recommended 2
  • For those starting at age 16 or older, a 3-dose series is recommended 1
  • HPV vaccination is recommended for both males and females 1

Meningococcal B Vaccine (MenB)

  • MenB vaccine may be administered to adolescents aged 16-23 years (preferred age is 16-18 years) based on individual clinical decision making 1
  • This is a relatively newer recommendation that provides protection against serogroup B meningococcal disease 1

Catch-Up Vaccines

If the 16-year-old has not received these vaccines previously, they should also receive:

  • Hepatitis B (HepB): Complete the 3-dose series if not already done 1
  • Measles, Mumps, Rubella (MMR): Ensure two doses have been received 1
  • Varicella: Ensure two doses have been received if no reliable history of chickenpox 1

Special Considerations

  • Influenza vaccine: Annual influenza vaccination is recommended for all adolescents 1
  • Pneumococcal vaccine: Recommended for adolescents with certain chronic illnesses or immunocompromising conditions 1
  • Hepatitis A vaccine: Recommended for adolescents with specific risk factors or who live in areas with high rates of hepatitis A 1

Implementation Considerations

  • The 16-year visit provides an important opportunity to ensure all recommended vaccines are up to date 4, 3
  • Coverage rates for adolescent vaccines remain below the Healthy People 2010/2020 targets of 90% 5, 6
  • All recommended vaccines can be administered during the same visit 3
  • Providers should review vaccination records at every healthcare encounter to identify and address any missing vaccines 2, 3

Common Pitfalls to Avoid

  • Missing the 16-year MenACWY booster: Many adolescents receive the first dose at 11-12 years but miss the crucial booster dose at age 16 3, 6
  • Incomplete HPV series: Coverage for completion of the HPV vaccine series is lower than for other adolescent vaccines 2, 3
  • Focusing only on Tdap: There are substantial missed opportunities when providers administer Tdap but not other recommended vaccines during the same visit 3
  • Not checking for catch-up needs: Some adolescents may have missed earlier childhood vaccines that should be completed during adolescence 1

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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