What is the relationship between intermittent fasting and increased lifespan?

From the Guidelines

Intermittent fasting has been shown to potentially extend lifespan based on promising research, though definitive human evidence is still emerging, with the most recent and highest quality study suggesting its benefits in reducing metabolic syndrome risk factors 1. The relationship between intermittent fasting and increased lifespan is complex, with various studies suggesting its potential benefits in improving cardiometabolic parameters, reducing atherosclerosis and diastolic dysfunction, and activating longevity pathways 1. Some of the key benefits of intermittent fasting include:

• Reducing oxidative stress and inflammation
• Improving insulin sensitivity
• Triggering cellular repair processes called autophagy
• Activating longevity pathways However, it is essential to note that intermittent fasting may not be suitable for everyone, particularly those with certain medical conditions, such as diabetes, pregnancy, or a history of eating disorders 1. To implement intermittent fasting safely, it is recommended to:
• Start gradually by extending your overnight fast to 12 hours, then slowly increase to your desired fasting window
• Stay well-hydrated with water, black coffee, or plain tea during fasting periods
• Consult with a healthcare provider before attempting intermittent fasting, especially if you have any underlying medical conditions The most practical approaches to intermittent fasting include time-restricted eating (limiting food intake to an 8-10 hour window daily) or the 5:2 method (eating normally five days per week and restricting calories to 500-600 on two non-consecutive days) 1. Overall, while the evidence is still emerging, intermittent fasting has shown promise in potentially extending lifespan and improving overall health, making it a worthwhile consideration for those looking to adopt a healthier lifestyle, as supported by the most recent study published in 2022 1.

From the Research

Relationship Between Intermittent Fasting and Increased Lifespan

• The relationship between intermittent fasting and increased lifespan has been studied in various research papers, with findings suggesting that intermittent fasting may have a positive impact on longevity 2, 3, 4.
• Intermittent fasting has been shown to affect cellular aging and disease risk factors, leading to improved healthspan and potentially increased lifespan 2.
• Studies have demonstrated that intermittent fasting can improve physiological function, enhance performance, and slow aging and disease processes, which may contribute to increased lifespan 3, 4.
• The beneficial effects of intermittent fasting on metabolism, endocrine and cardiovascular systems, cancer prevention, brain health, neurodegeneration, and aging may also play a role in increasing lifespan 3, 4, 5.

Mechanisms Underlying the Relationship

• The mechanisms underlying the relationship between intermittent fasting and increased lifespan are thought to involve optimization of energy utilization, activation of adaptive cellular stress response signaling pathways, and enhancement of mitochondrial health, DNA repair, and autophagy 3, 4.
• Intermittent fasting has also been shown to promote stem cell-based regeneration and long-lasting metabolic effects, which may contribute to increased lifespan 4.
• The reduction in proliferation markers such as IGF-1, which can act as an accelerator of tumor development and progression, may also be an indicator of the potential benefits of intermittent fasting for increasing lifespan 6.

Evidence from Human Studies

• Human studies have demonstrated that intermittent fasting can improve quality of life, reduce fatigue, and improve various health indicators, including insulin resistance and cardiovascular disease risk factors 5, 6.
• A prospective clinical trial found that intermittent fasting significantly improved quality of life and decreased fatigue in healthy volunteers, while maintaining a good safety profile 6.
• Further research is needed to establish the long-term effectiveness of intermittent fasting for weight loss and metabolic health, as well as its potential benefits for increasing lifespan 3, 5.