From the Research
Buproparmine (Wellbutrin) is not typically a first-line treatment for Generalized Anxiety Disorder (GAD), but it may be considered in certain cases, such as when first-line treatments fail or when a patient has comorbid depression with low energy or motivation. According to the most recent and highest quality study, 1, the effective pharmacological treatments for GAD include duloxetine, escitalopram, pregabalin, quetiapine, and venlafaxine.
Treatment Options for GAD
The current consensus guidelines for treatment of GAD recommend first-line treatment with either a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) 2. These medications, such as sertraline or escitalopram, are typically started at 25-50mg daily and gradually increased to therapeutic doses.
Role of Buproparmine in GAD Treatment
Buproparmine (Wellbutrin) works differently from standard anxiety medications by affecting dopamine and norepinephrine rather than serotonin. While it may be effective for some people with GAD, its use is generally considered when first-line treatments fail or when a patient has comorbid depression with low energy or motivation 3. The typical dosage ranges from 150-300mg daily of the XL formulation.
Important Considerations
Some patients find Wellbutrin helpful for anxiety, while others experience increased anxiety or agitation as side effects 4. This variability occurs because bupropion's stimulating properties can either help overcome anxiety-related fatigue or potentially worsen anxiety symptoms. Treatment should continue for at least 6-12 months after symptom improvement, with any discontinuation done gradually under medical supervision 5.